Methods of enhancing solubility of compounds
AssigneeFormatech, Inc.
InventorsJohn G. Augustine, Kaliappanadar Nellaiappan, Benjamin S. Isaacs, Indu J. Isaacs
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Abstract
This invention concerns novel methods of enhancing the solubility of a compound. Compositions prepared using such methods are also disclosed. Compositions prepared using the methods have various advantages over conventionally known compositions.
Claims67
A method of enhancing the solubility of a compound, said method comprising:
- (a) contacting the compound with a fatty acid under conditions in which said fatty acid does not substantially form micelles;
- and then (b) altering said conditions such that said fatty acid forms micelles in the presence of the compound.
A method of enhancing the solubility of a hydrophobic pharmaceutical compound, said method consisting essentially of contacting the compound with a fatty acid salt.
A method of formulating paclitaxel, said method comprising:
- (a) contacting paclitaxel with oleic acid to form a mixture;
- and then (b) adding ethanolamine to said mixture to form a solution.
A method of formulating paclitaxel, said method comprising contacting paclitaxel with a fatty acid salt, wherein said fatty acid salt is sodium oleate, sodium caprylate, or sodium linoleate.
A method of formulating a pharmaceutical composition, said method comprising:
- (a) contacting a pharmaceutical compound with a fatty acid under conditions in which said fatty acid does not substantially form micelles;
- and then (b) altering said conditions such that said fatty acid forms micelles in the presence of the pharmaceutical compound.
A method of formulating a pharmaceutical composition, said method comprising contacting a hydrophobic pharmaceutical compound with a fatty acid salt.
Dependencies are inferred from the claim text.