Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders

A compound of Formula (III),

• wherein,
• K is a a monovalent charged anion selected from halide, nitrate, or nitrite;
• R12 and R13 are hydrogen or, when taken together are oxygen;
• R14 is lower alkyl or haloalkyl;
• R15 is selected from:
• wherein Rv is selected from D or M;
• D is (i) hydrogen
• (ii) —NO
• (iii) —NO2
• (iv) —CH(Rd)—O—C(O)—Y—(C(Re)(Rf))p-T-Q;
• (v) —C(O)-T1-(C(Re)(Rf))p-T2-Q;
• or
• (vi) —C(O)-T-(C(Ry)(Rz))p;
• Rd is hydrogen, lower alkyl, cycloalkyl, aryl, alkylaryl or heteroaryl;
• Y is oxygen, sulfur or NRi;
• Ri is hydrogen, lower alkyl, lower haloalkyl or heteroaryl;
• Re and Rf are each independently hydrogen, lower alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl, alkylamino, dialkylamino, or carboxy, or Re and Rf taken together with the carbon atom to which they are attached are carbonyl, cycloalkyl or bridged cycloalkyl;
• p is an integer from 1 to 6;
• T, T1 and T2 are each independently a covalent bond, oxygen, sulfur or nitrogen;
• Q is —NO or —NO2;
• with the proviso that in “T-Q” and “T2-Q”, T and T2 cannot be a covalent bond;
• Ry and Rz are each independently -T1-(C(Re)(Rf))p-G-(C(Re)(Rf))p-T2-Q;
• G is a covalent bond, -T-C(O)—, —C(O)-T or Y;
• wherein Rd, Re, Rf, p, Q, T, T1, T2 and Y are as defined herein;
• M is (i) —C(O)-T-(C(Re)(Rf))p-G-(C(Re)(Rf))p—N(N—(O−)·N═O)—Ri or
• (ii) —CH(Rd)—O—C(O)-T-(C(Re)(Rf))p-G-(C(Re)(Rf))p—N(N—(O31)·N═O)—Ri;
• wherein T, Re, Rf, p, G, Ri, and Rd are as defined herein;
• and
• with the proviso that the compounds of Formula (III) must contain at least one —NO group or at least one —NO2 group, and wherein the at least one —NO group or the at least one —NO2 group is linked to the compounds of Formula (III) through an oxygen atom, a nitrogen atom or a sulfur atom.