Use of adenoviruses mutated in the VA genes for cancer treatment
AssigneeOncolytics Biotech Inc.
InventorsRamon Alemany Bonastre, Manel Maria Piqueras
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Abstract
This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene sequence or both. This adenovirus may also have mutations in the sequences controlling expression of the VA RNAs.
Claims15
A method of treating cancer comprising administering, to a subject having cancer, an adenovirus having mutated VAI and VAII RNA genes, wherein said adenovirus is defective in its VAI and VAII virus-associated RNAs and will selectively replicate in cells of said cancer.
A method of treating cancer comprising administering, to a subject having cancer, an adenovirus comprising:
- (A) one or a combination of (i) a mutation within a VAI gene;
- (ii) a mutation in a sequence before a VAI gene that controls the expression of said gene;
- or (iii) a mutation in a sequence after a VAI gene that controls termination of transcription of said gene, and
- (B) one or a combination of (i) a mutation within a VAII gene;
- (ii) a mutation in a sequence before a VAII gene that controls the expression of said gene;
- or (iii) a mutation in a sequence after a VAII gene that controls termination of transcription of said gene,
- wherein said mutations result in defective VAI and VAII virus-associated RNAs, and wherein
- said adenovirus will selectively replicate in cells of said cancer.
Dependencies are inferred from the claim text.