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US 7,335,391 B1Granted
Method for coating implantable devices
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorStephen D. Pacetti
Life of this patent
Estimating the term…
Abstract
A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure.
Claims27
A method of forming a coating for an implantable medical device, comprising:
- inserting the device into a chamber;
- adjusting the pressure of the chamber to a pressure greater than ambient pressure;
- followed by applying a composition comprising a solvent to the implantable device while the device is disposed in an environment having the pressure at greater than ambient pressure,
- wherein a coating is formed on the device through evaporation of the solvent.
1 more element
A method of forming a coating for an implantable medical device, comprising
- inserting the device into a chamber;
- adjusting the pressure of the chamber to a pressure greater than ambient pressure;
- applying a composition comprising a solvent and a therapeutic substance to the implantable device while the device is disposed in an environment having the pressure at greater than ambient pressure, wherein the act of applying comprises spraying the composition on the implantable device;
- and
- wherein the therapeutic substance is
- an antiproliferative antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antioxidant, or a combination of these;
- or
- an antibiotic combined with an antiproliferative antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antioxidant, or a combination of these.
5 more elements
A method of forming a coating for an implantable medical device, comprising
- inserting the device into a chamber;
- adjusting the pressure of the chamber to a pressure greater than ambient pressure;
- applying a composition comprising:
- a solvent;
- and
- a therapeutic substance,
- to the implantable device while the device is disposed in an environment having the pressure at greater than ambient pressure
- wherein the pressure is selected based on the vapor pressure of the solvent and wherein the therapeutic substance is
- an antiproliferative antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antioxidant, or a combination of these;
- or
- an antibiotic combined with an antiproliferative antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antioxidant, or a combination of these.
8 more elements
Dependencies are inferred from the claim text.