Fusion antigen used as vaccine
AssigneeAnimal Technology Institute Taiwan
InventorsChao-Wei Liao, Chung-Nan Weng
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Abstract
The present invention mainly provides a fusion antigen specific for a target cell comprising a ligand moiety which is capable of reacting, recognizing or binding to the receptors on the target cell, a Pseudomonas exotoxin A translocation domain II, an antigenic moiety, and a carboxyl terminal moiety which permits combination of the fusion antigen to the endoplasmic reticulum (ER) membrane of the target cell. A method of immunizing an animal using the fusion antigen is also provided.
Claims22
A fusion antigen specific for a target cell comprising:
- an antigenic moiety;
- a ligand moiety which is capable of reacting, recognizing or binding to a receptor on the target cell;
- a Pseudomonas exotoxin A translocation domain II;
- and
- a carboxyl terminal moiety comprising SEQ ID NO:
- 10.
A fusion porcine reproductive and respiratory syndrome virus (PRRSV) ORF 7 antigen comprising
- a PRRSV ORF 7 moiety;
- a Pseudomonas exotoxin A binding domain I;
- a Pseudomonas exotoxin A translocation domain II;
- and
- a carboxyl terminal moiety comprising SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.