Sensor with improved shelf life
AssigneeLifeScan, Inc.
InventorsAlastair McIndoe Hodges, Ronald Chatelier
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Abstract
The present invention provides a metal electrode stabilized by a coating, the coating comprising a sulfur containing moiety in its molecular structure. The coating may also include a hydrophilic group and a spacer between the sulfur containing moiety and the hydrophilic group. Preferably, the sulphur-containing moiety is selected from the group comprising thiol, disulphide and SOx, and the hydrophilic group is selected from the group comprising hydroxyl, amine, carboxyl, carbonyl, oligo (ethylene oxide) chain, and zwitterionic species. Compounds useful in the present invention include 2-mercaptoethanol, 2-mercaptoethylamine, 3-mercaptopropionic acid, thiophene, 4-carboxythiophene, cysteine, homocysteine, and cystine.
Claims15
A coated metal electrode, the metal electrode comprising a coating and an overcoating, wherein the overcoating comprises a surfactant, wherein the coating comprises a sulfur containing moiety in its molecular structure, wherein
- the coating does not result in a loss of the sensing characteristics of the electrode, and wherein;
- the coating is selected from the group consisting of 2-mercaptoethanol, 2-mercaptoethylamine, thiophene, L-cysteine, L-cystine, D-cysteine, D-cystine, L-homocysteine, D-homocysteine, and wherein;
- a temporal stability of the coated metal electrode is greater than a temporal stability of a corresponding uncoated metal electrode.
A method of preparing a metal electrode stabilized by a coating, the method comprising:
- contacting a metal electrode with a substance comprising a sulfur containing moiety in its molecular structure;
- and thereafter contacting the metal electrode with a surfactant, whereby a coated metal electrode is obtained, wherein
- the coating does not result in a loss of the sensing characteristics of the electrode, and wherein;
- the coating is selected from the group consisting of 2-mercaptoethanol, 2-mercaptoethylamine, 3-mercaptopropionic acid, thiophene, L-cysteine, L-cystine, D-cysteine, D-cystine, L-homocysteine, D-homocysteine, and wherein
- a temporal stability of the coated metal electrode is increased relative to that of a corresponding uncoated metal electrode.
A method of sensing an analyte, the method comprising:
- contacting a sample comprising an analyte to a metal electrode, the metal electrode comprising a coating and an overcoating, wherein the overcoating comprises a surfactant, wherein the coating comprises a sulfur containing moiety in its molecular structure, wherein
- the coating does not result in a loss of the sensing characteristics of the electrode, and wherein;
- the coating is selected from the group consisting of 2-mercaptoethanol, 2-mercaptoethylamine, 3-mercaptopropionic acid, thiophene, L-cysteine, L-cystine, D-cysteine, D-cystine, L-homocysteine, D-homocysteine, and wherein
- a temporal stability of the coated metal electrode is greater than a temporal stability of a corresponding uncoated metal electrode;
- and obtaining a measurement indicative of a presence of the analyte in the sample.
Dependencies are inferred from the claim text.