Nanoparticle delivery vehicle

A nanoparticle delivery vehicle for contacting a target cell and crossing a cellular membrane and a nuclear membrane of a target cell, the nanoparticle delivery vehicle comprising:

• (a) a nanoparticle, wherein the nanoparticle comprises a material selected from the group consisting of cadmium selenide, titanium, titanium dioxide, tin, tin oxide, silicon, silicon dioxide, iron, ironIII oxide, silver, nickel, gold, copper, aluminum, steel, cobalt-chrome alloy, titanium alloy. brushite, tricalcium phosphate, alumina, silica, zirconia, diamond, polystyrene, silicone rubber, polycarbonate, polyurethanes, polypropylenes, polymethylmethaacrylate, polyvinyl chloride, polyesters, polyethers, and polyethylene;
• (b) an active agent;
• (c) a nuclear localization signal;
• and
• (d) one or more extracellular targeting agents, wherein the one or more extracellular targeting agents is recognized and bound by one or more receptors on a surface of a target cell;
• wherein the nuclear localization signal or one of the one or more extracellular targeting agents is selected from the group consisting of SEQ ID NOs:
• 4-6, and combinations thereof.

A nanoparticle delivery vehicle for contacting a target cell and crossing a cellular membrane and a nuclear membrane of a target cell, the nanoparticle delivery vehicle comprising:

• (a) a nanoparticle, wherein the nanoparticle comprises a material selected from the group consisting of cadmium selenide, titanium, titanium dioxide, tin, tin oxide, silicon, silicon dioxide, iron, ironIII oxide, silver, nickel, gold, copper, aluminum, steel, cobalt-chrome alloy, titanium alloy, brushite, tricalcium phosphate, alumina, silica, zirconia, diamond, polystyrene, silicone rubber, polycarbonate, polyurethanes, polypropylenes, polymethylmethaacrylate, polyvinyl chloride, polyesters, polyethers, and polyethylene;
• (b) an active agent;
• (c) a nuclear localization signal;
• and
• (d) one or more extracellular targeting agents, wherein the one or more extracellular targeting agents is recognized and bound by one or more receptors on a surface of a target cell;
• wherein the nuclear localization signal comprises SEQ ID NO:
• 4 and one of the one or more extracellular targeting agents comprises SEQ ID NO:
• 5.

A nanoparticle delivery vehicle for contacting a target cell and crossing a cellular membrane and a nuclear membrane of a target cell, the nanoparticle delivery vehicle comprising:

• (a) a nanoparticle, wherein the nanoparticle comprises a material selected from the group consisting of cadmium selenide, titanium, titanium dioxide, tin, tin oxide, silicon, silicon dioxide, iron, ironIII oxide, silver, nickel, gold, copper, aluminum, steel, cobalt-chrome alloy, titanium alloy, brushite, tricalcium phosphate, alumina, silica, zirconia, diamond, polystyrene, silicone rubber, polycarbonate, polyurethanes. polypropylenes, polymethylmethaacrylate, polyvinyl chloride, polyesters, polyethers, and polyethylene;
• (b) an active agent;
• (c) a nuclear localization signal;
• and
• (d) one or more extracellular targeting agents, wherein the one or more extracellular targeting agents is recognized and bound by one or more receptors on a surface of a target cell;
• wherein the nuclear localization signal and one of the one or more extracellular targeting agents together comprise SEQ ID NO:
• 6.

A nanoparticle delivery vehicle for contacting a target cell and crossing a cellular membrane and a nuclear membrane of a target cell, the nanoparticle delivery vehicle comprising:

• (a) a nanoparticle;
• (b) an active agent;
• (c) a nuclear localization signal;
• and
• (d) one or more extracellular targeting agents, wherein the one or more extracellular targeting agents is recognized and bound by one or more receptors on a surface of a target cell;
• wherein the nuclear localization signal or one of the one or more extracellular targeting agents is selected from the group consisting of SEQ ID NOs:
• 4-6, and combinations thereof.