Polypeptide variants with altered effector function

An antibody comprising a variant human IgG1 Fc region, which antibody comprises an amino acid substitution at two or more of amino acid positions 265, 269, 270, 297 or 327 of the Fc region, wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.

An antibody comprising a variant human IgG1 Fc region, wherein the amino acid residue at any one or more of amino acid positions 265 or 269 of the Fc region is substituted with Ala, and wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.

An antibody that binds to vascular endothelial growth factor (VEGF) comprising a variant human IgG1 Fc region, which antibody comprises an amino acid substitution at any one or more of amino acid positions 265 or 269 of the Fc region, wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.

An immunoadhesin comprising a variant human IgG1 Fc, which immunoadhesin comprises an amino acid substitution at any one or more of amino acid positions 265 or 269 of the Fc region, wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.

An immunoadhesin comprising a variant human IgG1 Fc region, which immunoadhesin comprises an amino acid substitution at two or more of amino acid positions 265, 269, 270, 297 or 327 of the Fc region, wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.

An immunoadhesin comprising a variant human IgG1 Fc region, wherein the amino acid residue at any one or more of amino acid positions 265 or 269 of the Fc region is substituted with Ala, and wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.