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US 7,332,513 B2Granted
Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof
AssigneeRenopharm Ltd.
InventorsPeter Assaf, Elham Gazaleen-Mariee, Michael Naveh
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Abstract
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
Claims4
An NO-donating compound having the general formula I:
- wherein:
- A is absent;
- X is a —C(═O)—R′ carbonyl group, whereas R′ is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, amine, halide, sulfonate, sulfoxide, phosphonate, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, cyano, nitro, azo, sulfonamide, carbonyl, C-carboxylate, O-carboxylate, N-thiocarbamate, O-thiocarbamate, urea, thiourea, N-carbamate, O-carbamate, C-amide, N-amide, guanyl, guanidine and hydrazine;
- B is a saturated or unsaturated, substituted or unsubstituted alkylene chain having 1-20 carbon atoms;
- Y is a —ONO2 group;
- and
- Z is selected from the group consisting of hydrogen and alkyl.
4 more elements
Dependencies are inferred from the claim text.