Methods for drug discovery, disease treatment, and diagnosis using metabolomics
AssigneesMatabolon, Inc., Cornell Research Foundation, Inc.
InventorsRima Kaddurah-Daouk, Bruce Kristal
Life of this patent
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Abstract
The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.
Claims78
A method for metabolomically identifying small molecules indicative of amyotrophic lateral sclerosis, comprising:
- obtaining a small molecule profile from a subject suffering from amyotrophic lateral sclerosis;
- and
- comparing the small molecule profile from the subject to a standard small molecule profile, thereby identifying small molecules indicative of amyotrophic lateral sclerosis, wherein said small molecule profile is obtained using one or more techniques which detect 50% or more of the small molecules in said sample.
A method for metabolomically identifying small molecules indicative of Parkinson's disease, comprising:
- obtaining a small molecule profile from a subject suffering from Parkinson's disease;
- and
- comparing the small molecule profile from the subject to a standard small molecule profile, thereby identifying small molecules indicative of Parkinson's disease, wherein said small molecule profile is obtained using one or more techniques which detect 50% or more of the small molecules in said sample.
A method for metabolomically identifying small molecules indicative of schizophrenia, comprising:
- obtaining a small molecule profile from a subject suffering from schizophrenia;
- and
- comparing the small molecule profile from the subject to a standard small molecule profile, thereby identifying small molecules indicative of schizophrenia, wherein said small molecule profile is obtained using one or more techniques which detect 50% or more of the small molecules in said sample.
A method for metabolomically identifying small molecules indicative of Parkinson's disease, comprising:
- obtaining a small molecule profile from a subject suffering from Parkinson's disease;
- and
- comparing the small molecule profile from the subject to a standard small molecule profile, thereby identifying small molecules indicative of Parkinson's disease, wherein small molecule profile is obtained using one or more techniques which detect 50% or more of the small molecules in said sample.
A method for metabolomically identifying small molecules indicative of depression, comprising:
- obtaining a small molecule profile from a subject suffering from depression;
- and
- comparing the small molecule profile from the subject to a standard small molecule profile, thereby identifying small molecules indicative of depression, wherein said small molecule profile is obtained using one or more techniques which detect 50% or more of the small molecules in said sample.
A method for metabolomically identifying small molecules indicative of schizophrenia, comprising:
- obtaining a small molecule profile from a subject suffering from schizophrenia;
- and
- comparing the small molecule profile from the subject to a standard small molecule profile, thereby identifying small molecules indicative of schizophrenia, wherein small molecule profile is obtained using one or more techniques which detect 50% or more of the small molecules in said sample.
Dependencies are inferred from the claim text.