Heterocyclic compounds as P2X7 ion channel blockers

A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof in combination with at least one pharmaceutically acceptable carrier, wherein said compound is of the formula (II):

• wherein:
• R is hydrogen, C1-6 alkyl, C2-6 acyl, C1-6 alkoxycarbonyl, or C6-12 aryloxycarbonyl;
• R1 and R3 are phenyl and wherein phenyl is optionally substituted with one or more substituents selected from the group consisting of halogen and C1-4 alkyl;
• R2 and R4 are the same or different and are each independently selected from:
• hydrogen, C1-6 alkyl or fluoroalkyl of the formula CnHxFy, wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from ito 9 and sum of x and y is 2n+1;
• R5 is phenyl, wherein phenyl is optionally substituted with one or more substituents selected from the group consisting of halogen, C1-4 alkyl, CF3, OCF3 and C1-4 alkoxy;
• X—Y is (CH2)a-Z-(CH2)b-, wherein Z is NR6;
• and wherein R6 is selected from:
• hydrogen, C1-6 alkoxy, C1-6 alkyl or fluoroalkyl of the formula CnHxFy, wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, wherein said alkoxy or alkyl or fluoroalkyl is optionally substituted with at least one substituent selected from the group consisting of:
• hydroxy, —SH, C1-4 alkoxy, C1-4 thioalkyl, C1-4 acyloxy, nitro, amino, C1-4 alkylamino, C1-4 dialkylamino, —CN, —CO2H, —CO2C1-4 alkyl, and aryl;
• a is an integer from 0 to 2 and b is an integer from 1 to 4.