Hemoactive compositions and methods for their manufacture and use
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsCary J. Reich, A. Edward Osawa, Helen Tran
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Abstract
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery.
Claims29
A dried hemoactive material for inhibiting bleeding or delivering an agent, comprising:
- a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood;
- and
- a non-cross-linked biologically compatible polymer which solubilizes when exposed to blood:
- wherein the cross-linked polymer is dispersed in a dried matrix of the non-cross-linked polymer.
A dried hemoactive material for inhibiting bleeding or delivering an agent, comprising:
- a non-cross-linked polymer comprising a dry gelatin matrix;
- and
- dry, cross-linked gelatin polymer particles dispersed in the dry non-cross-linked gelatin matrix.
A method for making a hemoactive material, said method comprising:
- dissolving in an aqueous medium a non-cross-linked biologically compatible polymer which solubilizes when exposed to blood;
- suspending in said aqueous medium containing the non-cross-linked polymer a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood;
- and
- drying the resulting aqueous medium containing both polymers to form a solid phase comprising the cross-linked polymer in dry form dispersed in a dry matrix of the non-cross-linked polymer.
Dependencies are inferred from the claim text.