Loading patent…
AssigneeNeuroNova AB
InventorsAnn Marie Janson, Jonas Frisen, Clas Johansson, Stefan Momma, Diana Clarke, Ming Zhao, Urban Lendahl, Kioumars Delfani
Estimating the term…
The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.
An isolated ependymal neural CNS stem cell from a mammal, wherein said stem cell expresses Notch 1 and one or more other cell surface proteins, wherein the cell surface protein is selected from the group consisting of Notch 2, Notch 3, CAR, and CFTR.
An isolated ependymal neural CNS stem cell from a mammal, wherein said stem cell comprises one or more cilia, and expresses Notch 1 and one or more other cell surface proteins, wherein the cell surface protein is selected from the group consisting of Notch 2, Notch 3, CAR, and CFTR.
A cell preparation comprising ependymal neural CNS stem cells from a mammal, wherein said preparation comprises at least 50% ependymal neural CNS stem cells.
A cell preparation comprising ependymal neural CNS stem cells from a mammal, wherein said preparation comprises at least 80% ependymal neural CNS stem cells.
A cell preparation comprising ependymal neural CNS stem cells from a mammal, wherein said preparation comprises at least 90% ependymal neural CNS stem cells.
A method of isolating ependymal neural CNS stem cells from a mammal, which method comprises the steps of:
A method of isolating ependymal neural CNS stem cells from a mammal, which method comprises the steps of:
A composition comprising the following ingredients:
A composition comprising the following ingredients:
Dependencies are inferred from the claim text.