Molecular antigen array

A process for producing a non-naturally occurring, ordered and repetitive antigen array comprising:

• a) providing a non-natural molecular scaffold comprising:
• (i) a core particle that is a virus-like particle of an RNA bacteriophage;
• and
• (ii) an organizer comprising at least one first attachment site, wherein said organizer is connected to said core particle by at least one covalent bond;
• and
• b) providing an antigen or antigenic determinant with at least one second attachment site, wherein said antigen or antigenic determinant is amyloid beta peptide (Aβ1-42) or a fragment thereof, and wherein said second attachment site is selected from the group consisting of:
• (i) an attachment site not naturally occurring with said antigen or antigenic determinant;
• and
• (ii) an attachment site naturally occurring with said antigen or antigenic determinant;
• and
• c) combining said non-natural molecular scaffold and said antigen or antigenic determinant;
• wherein said second attachment site associates with said first attachment site through at least one non-peptide bond such that said antigen or antigenic determinant and said non-natural molecular scaffold interact through said association to form an ordered and repetitive antigen array.