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US 7,319,170 B2Granted
N-cyclohexylaminocarbonyl benzensulfonmide derivatives
AssigneeMerck & Co., Inc.
InventorsSoumya P. Sahoo, Hiroo Koyama, Daniel J. Miller
Life of this patent
Estimating the term…
Abstract
A class of N-cyclohexylaminocarbonyl benzenesulfonamide derivatives are agonists or partial agonists or antagonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
Claims17
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of H, Cl, F, and C1-4alkyl, where C1-4alkyl is optionally substituted with 1-3 halogen atoms independently selected from F and Cl;
- R2 is selected from the group consisting of H, Cl, F, C1-4alkyl, OC1-4alkyl, and —S(O)2CH3, where C1-4alkyl and OC1-4alkyl are optionally substituted with 1-3 halogen atoms independently selected from F and Cl;
- R3, R4 and R5 are independently selected from the group consisting of hydrogen, F, Cl, C1-3alkyl, and —OC1-3alkyl, where C1-3alkyl and —OC1-3alkyl are optionally substituted with 1-3 halogens independently selected from F and Cl;
- X and Y are each independently selected from the group consisting of O, S, SO, and SO2;
- and
- n represents an integer selected from 1, 2, 3, and 4.
4 more elements
The compound which is selected from the compounds below, or a pharmaceutically acceptable salt thereof:
Dependencies are inferred from the claim text.