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US 7,318,841 B2Granted
Synthesis of calcium phosphates by mechano-chemical process
AssigneeEtex Corporation
InventorsAliassghar Tofighi, Christian Rey
Life of this patent
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Abstract
A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.
Claims20
A calcium phosphate self-setting paste, comprising:
- a powder consisting of a single calcium phosphate selected from the group consisting of monocalcium phosphate, calcium metaphosphate, heptacalcium phosphate, dicalcium phosphate dihydrate, tetracalcium phosphate, octacalcium phosphate, calcium pyrophosphate and tricalcium phosphate, wherein said calcium phosphate is the only source of calcium and phosphate ions in said paste and said powder has an average crystalline domain size of less than about 100 nm and a tap density of greater than 0.7 g/cm3;
- and
- a carrier fluid in an amount sufficient to form said paste, wherein said paste is capable of hardening at body temperature in less than 30 minutes.
Dependencies are inferred from the claim text.