US 7,317,086 B2 · Basal cell carcinoma tumor suppressor protein

Basal cell carcinoma tumor suppressor protein

AssigneeThe United States of America as represented by the Department of Health and Human Services

InventorsMichael C. Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G. Zaphiropoulos, Mae R. Gailani, Susan M. Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne B. Unden, Susan A. Gilles, Kylie Negus, Ian McLeod Smyth, Carol L. Pressman, David J. Leffell, Bernard Gerrard, Alisa M. Goldstein, Brandon Wainwright, Rune C. M. Toftgard, Georgia Chenevix-Trench, Allen E. Bale

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Abstract

This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.

Claims7

Dependent claims

An isolated protein that is at least 98% identical to SEQ ID NO.:60 when said isolated protein is compared over its full length to SEQ ID NO.:60 over its full length.

Dependencies are inferred from the claim text.