Tetralin and indane derivatives and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• m is from 0 to 3;
• p is from 1 to 3;
• q is 0, 1 or 2;
• Ar is optionally substituted aryl or optionally substituted heteroaryl;
• is an optional bond;
• each R1 is independently halo, alkyl, haloalkyl, alkoxy, hydroxy, heteroalkyl, cyano, —S(O)t—Ra, —C(═O)—NRbRc, —SO2—NRbRc, —N(Rd)—C(═O)—Re, or —C(═O)—Re, where t is from 0 to 2, Ra, Rb, Rc, Rd and Re each independently is hydrogen or alkyl, and Rf is hydrogen, alkyl, alkoxy or hydroxy;
• R2 is
• n is from 1 to 3;
• R3 and R4 each independently is hydrogen or alkyl, or R3 and R4 together may form ═O or ═NRf wherein Rf is hydrogen or alkyl;
• and
• one of R5 and R6 is hydrogen or alkyl and the other is:
• hydrogen;
• alkyl;
• amidinyl;
• aminocarbonyl;
• alkylcarbonyl;
• alkoxycarbonyl;
• aminocarbonylalkyl;
• aminoalkylcarbonyl;
• alkoxycarbonylalkyl;
• imidazolonyl;
• imidazolylcarbonyl;
• pyrrolylcarbonyl;
• pyrrolidinylcarbonyl;
• N-cyanoamidinyl;
• alkylsulfonyl;
• hydroxyalkylcarbonyl;
• aminosulfonyl;
• hydroxyalkyl;
• alkoxalkyl;
• alkylsulfonylalkyl;
• or optionally substituted heteroaryl;
• or
• R5 and R6 together with the nitrogen to which they are attached may form an amidinyl group, a urea group, a guanidinyl group or a five- or six-membered heteroaryl or heterocyclyl ring that is optionally substituted and which optionally includes an additional heteroatom selected from O, N and S;
• or
• one of R5 and R6 and one of R3 and R4 together with the atoms to which they are attached may form a five- or six-membered ring that optionally includes an additional heteroatom selected from O, N and S.