Polyene oxazoles and processes for their preparation
AssigneeThallion Pharmaceuticals Inc.
InventorsJames B. McAlpine, Chris M. Farnet, Emmanuel Zazopoulos, Nargis Ismail, Brian O. Bachmann
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Abstract
Polyene oxazoles of the following formula wherein R3 is selected from H and methyl, are disclosed. Such compounds, and pharmaceutically acceptable salts thereof, may be used in the inhibition of tumor cell growth. The polyene oxazoles and their pharmaceutically acceptable salts may be formulated as pharmaceutical compositions with pharmaceutically acceptable carriers for use in the inhibition of tumor cells. The polyene oxazoles may be obtained from strains of Streptomyces sparsogenes, such as strain 022 having deposit number IDAC 270504-04.
Claims16
A compound of the formula
- wherein R3 is selected from H and methyl;
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising compound of the formula
- wherein R3 is selected from H and methyl;
- or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound of the formula
- or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound of the formula
- or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.
A polyene oxazole obtained by a method comprising
- (a) cultivating a Streptomyces sparsogenes strain, wherein said cultivation is performed under aerobic conditions in a nutrient medium comprising at least one source of carbon atoms and at least one source of nitrogen atoms;
- and
- (b) isolating a polyene oxazole from the strain cultivated in step (a), wherein said polyene oxazole is a compound of the formula
A polyene oxazole obtained by a method comprising
- (a) cultivating a Streptomyces sparsogenes strain, wherein said cultivation is performed under aerobic conditions in a nutrient medium comprising at least one source of carbon atoms and at least one source of nitrogen atoms;
- and
- (b) isolating a polyene oxazole from the strain cultivated in step (a), wherein said polyene oxazole is a compound of the formula
Streptomyces sparsogenes having IDAC accession number 270504-04.
Dependencies are inferred from the claim text.