Macrocyclic pyrimidines, their production and use as pharmaceutical agents

Compounds of formula I

• in which
• A stands for phenylene,
• B stands for a bond or for C1-C12-alkylene, C2-C12-alkenylene, C2-C12-alkinylene, C3-C8-cycloalkylene, or phenylene that is optionally substituted in one or more places in the same way or differently with hydroxy, halogen, cyano, nitro, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C10-cycloalkyl, C1-C6-hydroxyalkyl, —(CH2)pSO3R8, or with the group —NR8R9, —NR8COR9, —NR8CSR9, —NR8SOR9, —NR8SO2R9, —NR8CONR8R9, —NR8COOR9, —NR8C(NH)NR9R10, —NR8CSNR9R10, —NR8SONR9R10, —NR8SO2NR9R10, —COR8, —CSR8, —S(O)R8, —S(O)2R8, —S(O)2NR8R9, —SO3R8, —CO2R8, —CONR8R9, —CSNR8R9, —SR8 or —CR8(OH)—R9,
• X and Y, in each case independently of one another, stand for oxygen, sulfur or for the group —NR11, —NR11(CH2)—, —NR11O—, —ONR11—, ═CR6R7, ═C═O, ═C═S, ═SO, ═SO2, —C(O)O—, —OC(O)—, —S(O)O—, —OS(O)—, —S(O)2O—, —OS(O)2—, —CONR8—, —N(COR8)—, —N(COOR8)—, —N(CONR8R9)—, —NR8CO—, —OCONR8—, —NR8C(O)O—, —CSNR8—, —NR8CS—, —OCSNR8—, —NR8CSO—, —SONR8—, —NR8SO—, —SO2NR8—, —S(O)2N(COR8)—, —NR8SO2—, —NR8CONR9—, —NR8CSNR9—, —NR8SONR9—, —NR8SO2NR9—, —NR8C(O)NR9— or —NR8C(S)NR9—,
• R1 and R5, in each case independently of one another, stand for hydrogen, hydroxy, halogen, nitro, cyano, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C10-cycloalkyl, the group —C1-C6-alkyloxy-C1-C6-alkyloxy, —(CH2)pPO3(R10)2, —NR8R9, —NR8COR9, —NR8CSR9, —NR8SOR9, —NR8SO2R9, —NR8CONR9R10, —NR8COOR9, —NR8C(NH)NR9R10, —NR8CSNR9R10, —NR8SONR9R10, —NR8SO2NR9R10—, —COR8, —CSR8, —S(O)R8, —S(O)(NH)R8, —S(O)2R8, —S(O)2NR8R9, —S(O)2N═CH—NR8R9—, SO3R8, —CO2H, —CO2R8, —CONR8R9, —CSNR8R9, —SR8 or —CR8(OH)—R9, or for C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkinyl, or C3-C10-cycloalkyl, that is substituted in one or more places in the same way or differently with hydroxy, C1-C6-alkoxy, halogen, phenyl or with the group —NR3R4, and the phenyl, C3-C10-cycloalkyl, C3-C12-aryl, and —(CH2)p—C3-C18-heteroaryl itself optionally can be substituted in one or more places in the same way or differently with halogen, hydroxy, C1-C6-alkyl, C1-C6-alkoxy, or with the group —CF3 or —OCF3—,
• R2 stands for hydrogen or C1-C10-alkyl,
• R3 stands for hydrogen, halogen, nitro, cyano, C1-C10-alkyl, halo-C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkinyl, C3-C10-cycloalkyl, hydroxy, C1-C6-alkoxy, C1-C6-alkylthio, amino, —NH—(CH2)p—C3-C10-cycloalkyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkoxy-C1-C6-alkyl, —NHC1-C6-alkyl, —N(C1-C6-alkyl)2, —SO(C1-C6-alkyl), —SO2(C1-C6-alkyl), C1-C6-alkanoyl, —CONR8R9, —COR10, C1-C6-alkylOAc, carboxy, or for the group —NR8R9, or for C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkinyl, or C3-C10-cycloalkyl, that is substituted in one or more places in the same way or differently with hydroxy, halogen, C1-C6-alkoxy, C1-C6-alkylthio, amino, cyano, C1-C6-alkyl, —NH—(CH2)p—C3-C10-cycloalkyl, C3-C10-cycloalkyl, C1-C6-hydroxyalkyl, C2-C6-alkenyl, C2-C6-alkinyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkoxy-C1-C6-alkyl, —NHC1-C6-alkyl, —N(C1-C6-alkyl)2, —SO(C1-C6-alkyl), —SO2(C1-C6-alkyl), C1-C6-alkanoyl, —CONR8R9, —COR10, C1-C6-alkylOAc, carboxy, —(CH2)pPO3(R10)2 or with the group —NR8R9,
• R4 stands for hydrogen, halogen or C1-C4-alkyl,
• R6, R7, R8,
• R9, R10
• and R11, in each case independently of one another, stand for hydrogen or for C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkinyl, C3-C10-cycloalkyl,
• m stands for 0 to 8, and
• n and p stand for 0 to 6, or isomers, diastereomers, enantiomers and salts thereof.