Conjugated nitro alkene anticancer agents based on isoprenoid metabolism
AssigneeArizona Biomedical Research Commission
InventorsSeth D. Rose, Karl J. Okolotowicz, Rosemarie F. Hartman, Jason Houtchens
Life of this patent
Estimating the term…
Abstract
Conjugated nitro alkene compounds hamper or prevent proliferation of cancer cells in cell culture and in cancer patients, which can result in a decrease in tumor size and/or disappearance of the cancer. The compounds may act by interference with cancer cell biochemistry, in which isoprenoid groups such as farnesyl and geranylgeranyl become bonded to various oncogenic proteins such as Ras, RhoA, RhoB, or some other growth-related cellular protein(s).
Claims6
A method for the treatment of cancer in a patient, the method comprising administering an effective amount of a compound of Formula (I) to a patient in need thereof
- or pharmaceutically acceptable salt thereof, wherein:
- A is
- B and G2 are independently hydrogen or methyl;
- and n is 0, 1, or 2.
A method for the treatment of cancer in a patient in need thereof, the method comprising administering an effective amount of a compound of Formula (I)
- or pharmaceutically acceptable salt thereof, wherein:
- A is hydrogen,
- B is hydrogen or methyl;
- G2 is hydrogen, methyl, or
- and
- n is 0, 1, or 2.
A method for the treatment of cancer in a patient in need thereof, the method comprising administering an effective amount of a compound of Formula (I)
- or pharmaceutically acceptable salt thereof, wherein:
- A is hydrogen, methyl,
- B is hydrogen;
- G2 is hydrogen, methyl, or
- and
- n is 0, 1,or 2.
A method for the treatment of cancer in a patient in need thereof, the method comprising administering an effective amount of a compound of Formula (I)
- or pharmaceutically acceptable salt thereof, wherein:
- A is hydrogen, methyl,
- B is hydrogen or methyl;
- G2 is methyl or
- and
- n is 0, 1, or 2.
A method for the treatment of cancer in a patient in need thereof, the method comprising administering an effective amount of a compound of Formula
- or pharmaceutically acceptable salt thereof, wherein:
- G1 is
- G2 is hydrogen, methyl, or
- and
- G3 is methyl, phenyl,
Dependencies are inferred from the claim text.