Epithelial tissue targeting agent
AssigneePlantbodies Corporation
InventorsMich B. Hein, Andrew C. Hiatt, John H. Fitchen
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Abstract
Targeting molecules for use in delivering biological agents to epithelial tissue are disclosed. Upon delivery, the biological agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molecules may be used, for example, for the delivery of therapeutic agents.
Claims17
A composition for delivery of a biological agent to a basolateral factor of an epithelial surface, said composition comprising a targeting molecule covalently linked via a peptide bond to at least one biological agent, wherein said targeting molecule comprises a polypeptide that:
- (a) forms a closed covalent loop;
- and (b) contains at least three peptide domains having beta-sheet character, each of the domains being separated by domains lacking beta-sheet character, wherein said targeting molecule comprises the J chain portion encoded by nucleotides 1-213 of SEQ ID NO:
- 8 and wherein said biological agent is not native to the targeting molecule and is not iodine.
Dependencies are inferred from the claim text.