Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors
AssigneeNew York University
InventorDaniel Meruelo
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Abstract
The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to Sindbis virus vectors which have a preferential affinity for high affinity laminin receptors (HALR). These vectors are efficiently targeted to tumors and have the ability to cause tumor necrosis.
Claims7
A method for treating a mammal suffering from a tumor that expresses greater amounts of High Affinity Laminin Receptors (HALRs) than normal cells of the same lineage, which method comprises systemically administering to a mammal harboring such a tumor an amount of a replication defective Sindbis virus vector effective to treat the tumor, wherein the vector has not been modified to target a tumor-specific cellular determinant, has a preferential affinity for HALRs, a Sindbis virus E2 HALR binding domain, has genes encoding Sindbis proteins nsp1-4 and does not carry a heterologous anti-tumor gene.
Dependencies are inferred from the claim text.