Antigen delivery compositions and methods of use
AssigneePDS Biotechnology Corporation
InventorsLeaf Huang, Zhengrong Cui, John Dileo, Su-Ji Han, Dileep P. Vangasseri
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Abstract
The present invention provides antigen delivery compositions and methods of using same to prevent or to treat cancers and other infectious diseases.
Claims5
A method of inducing an immune response in a subject comprising administering to the subject an antigen/lipid complex comprising an antigen and a cationic lipid selected from the group consisting of 1,2-myristoyl-3-trimethylammonium propane (DMTAP), 1,2-distearoyl-3-trimethylammonium propane (DSTAP), 1,2-palmitoyl-3-trimethylammonium propane (DPTAP), 1,2-oleoyl-3-trimethylammonium propane (DOTAP), 1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (DPEPC), 1,2-distearoyl-sn glycerol-3-ethylphosphocholine (DSEPC), 1,2-dimyristoyl-sn-glycero-3-ethylphophocholine (DMEPC), 1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (DLEPC), 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOEPC), O,O′-dimyristyl-N-lysyl-aspartate (DMKE), O,O′-dimyristyl-N-lysyl-glutamate (DMKD), 2,3-dioleyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium trifluoracetate (DOSPA), N-[1-(2,3-dioleyloxy)propyl]-n,n,n-trimethylammonium chloride (DOTMA) and combinations thereof to form an antigen/lipid complex to induce an immune response in the subject.
Dependencies are inferred from the claim text.