Enzyme treatment of foodstuffs for Celiac Sprue
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsFelix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
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Abstract
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
Claims15
A method for treating a gluten-containing foodstuff to render said foodstuff less toxic to a Celiac Sprue patient, said method comprising contacting said foodstuff in vivo in said patient with a purified or recombinant prolyl endopeptidase orally administered to said patient, wherein said prolyl endopeptidase has a kcat/Km of at least 250 s−1 M−1 for cleaving PQPQLPYPQPQLPY (SEQ ID NO:3) under physiologic conditions, and wherein immunogenic gluten peptides in gluten-containing foodstuffs are cleaved into non-toxic fragments during said contacting step.
Dependencies are inferred from the claim text.