Immobilized bioactive hydrogel matrices as surface coatings
AssigneeEncelle, Inc.
InventorsFrancis V. Lamberti, Richard Chris Klann, Ronald Stewart Hill
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.
Claims51
A coated substrate, comprising:
- a substrate having a surface, wherein the substrate is a medical device;
- and
- a bioactive hydrogel matrix layer overlying the surface of the substrate and immobilized thereon, the hydrogel matrix layer comprising a polyglycan, a tissue-derived or synthetic polypeptide, and at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof.
A coated substrate, comprising:
- a substrate having a surface, wherein the substrate is a medical device;
- and
- a bioactive hydrogel matrix layer overlying the surface of the substrate and immobilized thereon, the hydrogel matrix layer comprising a polyglycan and a polypeptide, wherein at least one of the polyglycan and polypeptide is covalently cross-linked to the surface of the substrate.
A coated substrate, comprising:
- a substrate having a surface, wherein the substrate is a medical device;
- and
- a bioactive hydrogel matrix layer comprising dextran or oxidized dextran and gelatin overlying the surface of the substrate and immobilized thereon.
Dependencies are inferred from the claim text.