# US 7,303,752 B2 · Hookworm vaccine

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- Number: US 7,303,752 B2
- Document ID: US7303752B2
- Status: Granted
- Kind: B2
- Application number: 10/825,692
- Filed: 2004-04-16
- Published: 2005-02-24
- Granted: 2007-12-04
- Earliest claimed: 2001-10-17
- Assignees: The George Washington University
- Inventors: Peter Hotez; James Ashcom; Mahnaz Bdamchian; Bin Zhan; Yan Wang; John Hawdon; Alexander Loukas; Angela Williamson; Brian Jones; Jeffrey Bethony; Gaddam Goud; Maria Elena Bottazzi; Susana Mendez
- Web page: https://patentgrep.com/patent/US7303752B2

## CPC

- A61K 39/0003: {Invertebrate antigens}
- A61K 2039/55577: {Saponins; Quil A; QS21; ISCOMS}
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

Preparations which elicit an immune response to hookworm antigens and which may be utilized as hookworm vaccines are provided. In addition, a method of increasing the effectiveness of vaccinations against infectious diseases in patients infected with hookworm is provided. The method involves chemically treating the hookworm infestation prior to administering the vaccine.

## Claims

### Claim 1

A method of reducing the worm burden of human hookworm Necator americanus in a mammal or eliciting an immune response in said mammal comprising the step of:
administering to said mammal an effective amount of a composition comprising Na-ASP-2 having the amino acid sequence of SEQ ID NO:69; an adult stage hookworm antigen selected from the group consisting of Na-APR-1 having the amino acid sequence of SEQ ID NO:8 and Na-CP-2 having the amino acid sequence of SEQ ID NO:84; and at least one adjuvant, wherein the immune response is directed against the Necator americanus antigens of the administered composition.

### Claim 2 (depends on 1)

The method of claim 1, wherein said adult stage hookworm antigen is Na-APR-1 having the amino acid of SEQ ID NO:8.

### Claim 3 (depends on 1)

The method of claim 1, wherein said at least one adjuvant comprises two different adjuvants.

### Claim 4 (depends on 3)

The method of claim 3, wherein one of said two different adjuvants is an aluminum hydroxide gel.