Treatment of inflammatory bowel disease with IFN-gamma inhibitors
AssigneeGenentech, Inc.
InventorsAvi J. Ashkenazi, Rebecca H. R. Ward
Life of this patent
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Abstract
The invention concerns a method for the prevention or treatment of inflammatory bowel disease by administering an interferon-γ inhibitor. The invention further concerns pharmaceutical compositions and bispecific molecules useful in such method.
Claims17
An isolated bispecific molecule comprising a first binding domain connected to a second binding domain, wherein the first binding domain comprises an antigen binding domain of an anti-IFN-γ antibody, and the second binding domain comprises a TNF-α inhibitor selected from the group consisting of an antigen binding domain of a TNF-α antibody, a receptor for TNF-α, and an antigen binding domain of a TNF-α receptor antibody.
Dependencies are inferred from the claim text.