Biomedical devices having improved surface characteristics
AssigneeNovartis AG
InventorsLynn Cook Winterton, Juergen Vogt, John Martin Lally, Friedrich Stockinger
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Abstract
Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.
Claims29
A contact lens, comprising:
- (a) a core material having no theoretical ionic charge and is a fluorine-containg or siloxane-containing polymeric material, wherein said core material is a copolymerization product of a composition including a silicone-containing monomer or macromer and a hydrophilic comonomer;
- and
- (b) a surface coating, including at least one layer of a polyanionic material which is non-covalently bonded to the core material which is not previously treated to increase its surface charge density.
A contact lens, including a core material, wherein said core material is a copolymerization product of a composition including a silicone-containing monomer or macromer and a hydrophilic comonomer, and surface coatings, wherein at least a portion of the surface of said product comprises:
- (a) a first coating of at least one polyionic material adhered to the core material via a dispersed charge distribution, wherein the polyionic material has functional groups;
- and
- (b) a second material which comprises groups reactive with the functional groups of the polyionic material so as to be covalently bonded to the first coating.
A contact lens comprising:
- (a) a core material having a disperse plurality of transitory or permanent charges on the surface of the material, wherein said core material has no theoretical ionic charge;
- wherein said core material is a copolymerization product of a composition including a silicone-containing monomer or macromer and a hydrophilic comonomer;
- and
- (b) a surface coating comprising at least one bilayer, said bilayer comprising:
- (1) a first polyionic material which is non-covalently bonded to the core material which is not previously treated to increase its surface charge density;
- and
- (2) a second polyionic material, having charges opposite of the charges of the first polyionic material, which is non-covalently bonded to the first polyionic material.
A contact lens comprising:
- (a) a core material having a substantially uncharged surface, wherein said core material is a copolymerization product of a composition including a silicone-containing monomer or macromer and a hydrophilic comonomer;
- and
- (b) a surface coating comprising at least one bilayer, said bilayer comprising:
- (1) a first polyionic material which is non-covalently bonded to the core material;
- and
- (2) a second poly ionic material, having charges opposite of the charges of the first polyionic material, which is non-covalently bonded to the first polyionic material.
Dependencies are inferred from the claim text.