Signal processing for measurement of physiological analytes

One or more microprocessors comprising Programming to control operating a sensing device to obtain two or more active signals, wherein (i) said sensing device is in operative contact with an analyte, (ii) said sensing device obtains an active signal from the analyte, and (iii) said active signal is specifically related to analyte amount or concentration present in a biological system:

• assigning a fractional weight to each of said two or more active signals;
• determining a weighted signal that accounts for the different contributions of each of said two or more active signals and their associated fractional weights:
• and
• performing a calibration step that converts the weighted signal to a measurement value indicative of the amount or concentration of analyte present in the biological system.
• wherein the sensing device uses an iontophoretic current to extract the analyte from the biological system.

A method for measuring an analyte amount or concentration present in a biological system, said method comprising:

• obtaining an active signal from the analyte, wherein said active signal is related to analyte concentration;
• repeating said obtaining to provide two or more active signals;
• assigning a fractional weight to each of said two or more active signals based on when the respective active signals were generated with respect to one another;
• determining a weighted signal that accounts for the different contributions of each of said two or more active signals and their associated fractional weights;
• and
• performing a calibration step which converts the weighted signal to a measurement value indicative of the amount or concentration of analyte present in the biological system.

A method for measuring an analyte amount or concentration present in a biological system, said method comprising:

• obtaining an active signal from the analyte, wherein said active signal is related to analyte concentration:
• repeating said obtaining to provide two or more active signals;
• assigning a fractional weight to each of said two or more active signals;
• determining a weighted signal that accounts for the different contributions of each of said two or more active signals and their associated fractional weights;
• and
• performing a calibration step which converts the weighted signal to a measurement value indicative of the amount or concentration of analyte present in the biological system,
• wherein the first collection reservoir is in contact with the skin or mucosal surface of the biological system and the analyte is extracted using an iontophoretic current applied to said skin or mucosal surface.

A method for measuring an analyte amount or concentration present in a biological system, said method comprising:

• obtaining an active signal from the analyte, wherein said active signal is related to analyte concentration;
• repeating said obtaining to provide two or more active signals;
• assigning a fractional weight to each of said two or more active signals;
• determining a weighted signal that accounts for the different contributions of each of said two or more active signals and their associated fractional weights;
• and
• performing a calibration step which converts the weighted signal to a measurement value indicative of the amount or concentration of analyte present in the biological system,
• wherein obtaining the active signal comprises a baseline background subtraction method to remove background noise from the active signal.

A method for measuring an analyte amount or concentration present in a biological system, said method comprising:

• obtaining an active signal from the analyte, wherein said active signal is related to analyte concentration;
• repeating said obtaining to provide two or more active signals;
• assigning a fractional weight to each of said two or more active signals;
• determining a weighted signal that accounts for the different contributions of each of said two or more active signals and their associated fractional weights;
• and
• performing a calibration which converts the weighted signal to a measurement value indicative of the amount or concentration of analyte present in the biological system,
• wherein the calibration entails the use of a neural network algorithm that correlates each weighted signal with a measurement value indicative of the concentration of analyte present in the biological system.