Method for biomolecular sensing and system thereof
AssigneeUniversity of Rochester
InventorsBenjamin Miller, Lewis Rothberg
Life of this patent
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Abstract
A sensing system and method for biomolecular sensing. The system includes: a receptor for the at least one target, the receptor including a substrate and a transparent coating on the substrate having front and back surfaces; a light source positioned to direct at least a portion of light from the light source toward the coating on the receptor; and a detector positioned to capture the light reflected from the front and back surfaces of the coating, the detector identifying presence of at least one target based on a change in the interference pattern of captured light.
Claims26
A sensor system for sensing at least one target, the system comprising:
- a receptor for the at least one target, the receptor comprising a substrate, a translucent coating on the substrate having front and back surfaces, and one or more adsorbates attached to the front surface of the coating, said one or more adsorbates being capable of recognizing the at least one target;
- a light source positioned to direct at least a portion of s-polarized light from the light source toward the coating on the receptor at a non-normal angle of incidence that is effective to result in a condition of near perfect interference where the reflectance is less than 10−4;
- and
- a detector positioned to measure the light reflected from the front and back surfaces of the coating, the detector identifying presence of at least one target based on the measured reflected light.
A method for sensing at least one target, the method comprising:
- providing a receptor for the at least one target, the receptor comprising a substrate, a translucent coating on the substrate having front and back surfaces, and one or more adsorbates attached to the front surface of the coating, said one or more adsorbates being capable of recognizing the at least one target;
- directing s-polarized light at the front and back surfaces of the coating on the receptor at a non-normal angle of incidence that is effective to result in a condition of near perfect interference where the reflectance is less than 10−4;
- measuring the s-polarized light reflected from the front and back surfaces of the coating on the receptor;
- and
- providing an output identifying the at least one target based on the measured reflected light.
Dependencies are inferred from the claim text.