Methods of treating restenosis
AssigneeThe General Hospital Corporation
InventorsRoger J. Hajjar, Anne-Marie Lompr, Larissa Lipskaia, Federica Del Monte
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Abstract
Restenosis in a subject can be treated by administering to a tissue, e.g., a blood vessel, of the subject an agent that increases SERCA activity. For example, a stent that is coated with the agent can be introduced into a blood vessel.
Claims8
A method of reducing restenosis in a subject following angioplasty, the method comprising directly administering to the injured blood vessel of said subject a nucleic acid that encodes a SERCA2a polypeptide, wherein the nucleic acid is a component of an adenovirus-based vector, thereby reducing restenosis.
A method of reducing restenosis in a subject folloeing angioplasty, the method comprising directly administering to the injured blood vessel of said subject a nucleic acid that encodes a SERCA2a polypeptide, wherein the nucleic acid is a component of an adeno-associated virus-based vector, thereby reducing restenosis,
Dependencies are inferred from the claim text.