US 7,291,462 B2 · TADG-15: an extracellular serine protease overexpressed in carcinomas

Abstract

The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.

Claims10

Dependent claims

A method for detecting TADG-15 mRNA in a sample, comprising the steps of:

(a) contacting a sample with a probe, wherein said probe is specific for TADG-15 mRNA transcribed from SEQ ID NO:
1;
and
(b) detecting binding of said probe to said TADG-15 mRNA in said sample.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/600,187Filed 20 Jun 2003 · division

Priority

20 Feb 1998

Published

US 2004/0086910 A16 May 2004

Granted

6 Nov 2007

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C12N 9/6424
From mammals: serine endopeptidases
A61K 40/19
Characterised by the cell type used: dendritic cells
A61K 40/24
Characterised by the effect or the function of the cells: antigen-presenting cells [APC]
A61K 40/4249
Proteinases: serine proteases, e.g. kallikrein

Family

Application09/027,337Parent of this continuation-in-part · filed 20 Feb 1998

Application09/421,213Parent of this division · filed 20 Oct 1999

Application09/654,600Parent of this division · filed 1 Sep 2000

US 2004/0086910 A1Pre-grant publication · published 6 May 2004

US 6,649,741 B1Parent of this division

US 7,022,821 B1Parent of this division

US 5,972,616 AParent of this continuation-in-part

Application09/421,213Parent of this continuation-in-part

US 7,291,462 B2This patent

From the US filing history. Foreign family members aren’t listed.

TADG-15: an extracellular serine protease overexpressed in carcinomas

Life of this patent

TADG-15: an extracellular serine protease overexpressed in carcinomas

Life of this patent

Abstract

Claims10