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US 7,289,835 B2Granted
Multivariate analysis of green to ultraviolet spectra of cell and tissue samples
AssigneeMasimo Laboratories, Inc.
InventorsJames Mansfield, Jenny Freeman
Life of this patent
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Abstract
This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.
Claims2
A method for processing in vivo skin auto fluorescence spectra emitted by a skin surface of a patient to determine a blood glucose level of the patient comprising the steps of:
- collecting clinical fluorescence spectra data and corresponding glucose values from a range of individuals, said spectra data responsive to irradiation of tissue at a plurality of wavelengths of energy;
- sorting said clinical fluorescence spectra data according to said glucose values;
- processing said sorted clinical fluorescence spectra data to reduce effects of noise;
- collecting fluorescence spectra data emitted from the skin surface of the patient;
- correcting the collected spectra data using multivariate analysis to account for skin surface variables;
- and
- determining a blood glucose level of the patient based on at least said corrected spectra data and said processed clinical fluorescence spectra data.
4 more elements
Dependencies are inferred from the claim text.