Therapeutic compositions and methods of use
AssigneeTrustees of Dartmouth College
InventorsGordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
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Abstract
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
Claims23
A pharmaceutically acceptable composition comprising a compound having the formula:
- wherein either A or B is a double bond such that when A is a double bond, C11 has substituted thereon ═X, and when B is a double bond, C12 has substituted thereon ═X;
- R1 may be substituted anywhere on the six-membered ring denoted by positions 1 through 10;
- wherein an R2 group may be substituted anywhere on the structure represented in formula (I);
- and n is a number from 0 to 100;
- wherein ═X, R1, R2, and R3 are selected from the group consisting of —OR′, alkyl, alkylamino, alkoxy, aryl, aralkyl, aryloxy, alkylthio, alkylcarboxyl, hydrogen, halo, amino, cyano, nitro, thiol and hydroxyl, wherein R′ is H or alkyl, alkylamino, alkoxy, aryl, aralkyl, aryloxy, alkylthio, alkylcarboxyl, said compound being dispersed in a liposome.
A composition comprising a triterpenoid compound effective for inhibiting IFN-γ-induced NO production in macrophages, said compound having an IC50 value of at least less than 0.6 μM, said compound being dispersed in a liposome.
A pharmaceutically acceptable composition comprising a compound having the formula:
- wherein either A or B is a double bond such that when A is a double bond, C11 has substituted thereon ═X, and when B is a double bond, C12 has substituted thereon ═X;
- R1 may be substituted anywhere on the six-membered ring denoted by positions 1 through 10;
- wherein an R2 group may be substituted anywhere on the structure represented in formula (I), and n is a number from 0 to 100, wherein ═X, R1, R2, and, R3 are selected from the group consisting of —OR′, alkyl, alkylamino, alkoxy, aryl, aralkyl, aryloxy, alkylthio, alkylcarboxyl, hydrogen, halo, amino, cyano, nitro, thiol and hydroxyl, wherein R′ is H or alkyl, alkylamino, alkoxy, aryl, aralkyl, aryloxy, alkylthio, alkylcarboxyl,
- said compound being dispersed in an oil and water emulsion.
A composition comprising a triterpenoid compound effective for inhibiting IFN-γ-induced NO production in macrophages, said compound having an IC50 value of at least less than 0.6 μM, said compound being dispersed in an oil and water emulsion.
A pharmaceutically acceptable composition comprising a compound having the formula:
- wherein either A or B is a double bond such that when A is a double bond, C11 has substituted thereon ═X, when B is a double bond, C12 has substituted thereon ═X;
- R1 may be substituted anywhere on the six-membered ring denoted by positions 1 through 10;
- wherein an R2 group may be substituted anywhere on the structure represented in formula (I), and n is a number from 0 to 100;
- wherein ═X, R1, R2, and R3 are selected from the group consisting of —OR′, alkyl, alkylamino, alkoxy, aryl, aralkyl, aryloxy, alkylthio, alkylcarboxyl, hydrogen, halo, amino, cyano, nitro, thiol and hydroxyl, wherein R is H or alkyl, alkylamino, alkoxy, aryl, aralkyl, aryloxy, alkylthio, alkylcarboxyl,
- said composition being formulated for oral delivery in a pharmaceutically acceptable carrier.
A composition comprising a triterpenoid compound effective for inhibiting IFN-γ-induced NO production in macrophages, said compound having an IC50 value of at least less than 0.6 μM, said composition being formulated for oral delivery.
Dependencies are inferred from the claim text.