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US 7,288,251 B2Granted
Antibodies to CD40
AssigneesAbgenix, Inc., Pfizer Inc.
InventorsVahe Bedian, Ronald P. Gladue, Jose Corvalan, Xiao-Chi Jia, Xiao Feng
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AssigneesAbgenix, Inc., Pfizer Inc.
InventorsVahe Bedian, Ronald P. Gladue, Jose Corvalan, Xiao-Chi Jia, Xiao Feng
Estimating the term…
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
A monoclonal antibody or an antigen-binding portion thereof that specifically binds to and activates human CD40, wherein said antibody or portion comprises:
A monoclonal antibody or an antigen-binding portion thereof that specifically binds to and activates human CD40, wherein said antibody or portion comprises:
A monoclonal antibody or an antigen-binding portion thereof that specifically binds to and activates human CD40, wherein said antibody or portion comprises a light chain variable region amino acid sequence comprising SEQ ID NO:
A monoclonal antibody that specifically binds to and activates human CD40, wherein said antibody comprises a light chain amino acid sequence comprising SEQ ID NO:
A monoclonal antibody having the heavy and light chain amino acid sequences of the antibody produced by hybridoma 21.4.1 having American Type Culture Collection (ATCC) accession number PTA-3605.
A monoclonal antibody or an antigen-binding portion thereof that specifically binds to and activates human CD40, wherein said antibody or portion comprises:
A monoclonal antibody that specifically binds to and activates human CD40, wherein said antibody comprises:
A monoclonal antibody or an antigen-binding portion thereof comprising the CDR1, CDR2, and CDR3 of the heavy chain amino acid sequence and the CDR1, CDR2, and CDR3 of the light chain amino acid sequence of the antibody produced by hybridoma 21.4.1 having American Type Culture Collection (ATCC) accession number PTA-3605.
Dependencies are inferred from the claim text.