Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants
AssigneeProtein Polymer Technologies, Inc.
InventorErwin R. Stedronsky
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Abstract
The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
Claims10
A kit for adhering or bonding a tissue adhesive to a tissue, the kit comprising:
- (a) a primer molecule selected from the group consisting of a chaotropic agent, a sulfonated aromatic compound, xanthene, a protein, and an oligopeptide:
- (b) a proteinaceous tissue adhesive;
- and
- (c) an adhesive cross-linking agent,
- wherein said primer molecule is capable of physically interacting with a component present in said tissue, thereby increasing the capability of said tissue to adhere to said tissue adhesive.
Dependencies are inferred from the claim text.