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US 7,285,565 B2Granted
Benzamides and related inhibitors of factor Xa
AssigneeMillennium Pharmaceuticals, Inc.
InventorsBing-Yan Zhu, Penglie Zhang, Lingyan Wang, Wenrong Huang, Erick A. Goldman, Wenhao Li, Jingmei Zuckett, Yonghong Song, Robert M. Scarborough
Life of this patent
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Abstract
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Claims8
A compound of the following formula:
- A-Q-D-E-G-J-X,
- wherein:
- A is a member selected from the group consisting of:
- Q is a direct link;
- D is a member selected from the group consisting of:
- E is a member selected from the group consisting of:
- —C(═O)—NH— and —NH—C(═O)—;
- G is
- G is substituted by 0-4 R1d groups and each R1d group is independently selected from the group consisting of:
- H, —CH3, —CF3, —Cl, —F, —Br, —NH2, —NMe2, —OH, —OMe, —NHSO2Me, —NO2, —CN, —C(═O)—OMe, —CO2H, —CONH2, —SO2NH2, —SO2CH3, —NHC(═O)Me, —C(═O)N(—Me)2, —CH2NH2, —CH2N(—Me)2, —CH2OH, —OCH2CO2H, —OCH2C(═O)—OMe, —OCH2C(═O)—NH2, —OCH2C(═O)N(—Me)2,
- J is a member selected from the group consisting of:
- —O—, —NH—, —C(═O)—NH— and —NH—C(═O)—;
- X is a member selected from the group consisting of:
- or a pharmaceutically acceptable isomer, salt, hydrates, solvate or prodrug derivative thereof.
11 more elements
Dependencies are inferred from the claim text.