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US 7,282,351 B2Granted
Prostatic growth factor
AssigneeHuman Genome Sciences, Inc.
InventorsPeter L. Hudson, Craig A. Rosen, Wei-Wu He
Life of this patent
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Abstract
The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using such polypeptides therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.
Claims17
An isolated nucleic acid molecule selected from the group consisting of:
- I. a first polynucleotide which hybridizes under stringent conditions to the complement of a second polynucleotide, wherein the first polynucleotide encodes a polypeptide which is capable of stimulating the proliferation of human endothelial cells in the presence of the comitogen ConA, and the second polynucleotide is selected from the group consisting of:
- (a) a polynucleotide encoding amino acid residues 1 to 295 of SEQ ID NO:2;
- (b) a polynucleotide encoding amino acid residues 2 to 295 of SEQ ID NO:2;
- (c) a polynucleotide encoding amino acid residues 16 to 295 of SEQ ID NO:2;
- (d) a polynucleotide encoding the amino acid sequence of a full-length prostatic growth factor (PGF) polypeptide having the amino acid sequence encoded by the coding sequence of the human PGF cDNA contained in ATCC Deposit No. 75902;
- (e) a polynucleotide encoding the amino acid sequence of a full-length (PGF) polypeptide, excluding the N-terminal methionine, having the amino acid sequence encoded by the coding sequence of the human PGF cDNA contained in ATCC Deposit No. 75902;
- (f) a polynucleotide encoding the amino acid sequence of the mature (PGF) polypeptide having the amino acid sequence encoded by the coding sequence of the human PGF cDNA of the clone deposited as ATCC Deposit No. 75902;
- and
- (g) a polynucleotide which hybridizes under stringent conditions to the full complement of the polynucleotide set forth in SEQ ID NO:1;
- II. a polynucleotide selected from the group consisting of:
- (h) a polynucleotide fragment of SEQ ID NO:1 comprising at least 30 contiguous nucleotides of SEQ ID NO:1;
- and
- (i) a polynucleotide fragment of SEQ ID NO:1 comprising at least 50 contiguous nucleotides of SEQ ID NO:1;
- and
- III. a polynucleotide fully complementary to the polynucleotide of (a), (b), (c), (d), (e), (f), (g), (h), or (i).
12 more elements
Dependencies are inferred from the claim text.