Methods and compositions for directing cells to target organs
AssigneeThe United States of America as represented by the Department of Veterans Affairs
InventorCatherine Phillips
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Abstract
The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering stem cells such as those derived from the bone marrow or from umbilical cord tissue. The methods are also useful for targeting a gene of interest to a tissue in a mammal by introducing a cell containing the gene of interest and administering a glycoconjugate to the mammal.
Claims35
A method for targeting a hematopoietic stem cell to the heart of a mammal comprising administering an asialoorosomucoid to the mammal prior to administration of the cell to the mammal, whereby the cell is directed to the heart.
A method for targeting a mesenchymal stem cell to the heart of a mammal comprising administering an orosomucoid to the mammal prior to administration of the cell to the mammal, whereby the cell is directed to the heart.
A method for targeting a hematopoietic stem cell to the liver of a mammal comprising administering an orosomucoid to the mammal prior to administration of the cell to the mammal, whereby the cell is directed to the liver.
A method for targeting a mesenchymal stem cell to the liver of a mammal comprising administering an asialoorosomucoid to the mammal prior to administration of the cell to the mammal, whereby the cell is directed to the liver.
Dependencies are inferred from the claim text.