Method and composition for treatment of skeletal dysplasias
AssigneeProChon Biotech Ltd.
InventorsMyriam Golembo, Avner Yayon
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Abstract
The present invention discloses pharmaceutical compositions for the treatment of skeletal dysplasias, comprising as an active ingredient at least one natriuretic peptide. Unexpectedly, it has been shown that the natriuretic factors may be effective for bone elongation in situations of abnormal bone growth especially for achondroplasia. The effects of the natriuretic peptide may be further enhanced by prolonging its residence time or action at the target site.
Claims30
A pharmaceutical composition for bone elongation or treating skeletal dysplasias comprising at least one natriuretic peptide variant set forth in SEQ ID NO:5 wherein Xaa=Leu, Ile, Val;
- Xbb=Lys, Leu, Met;
- Xcc=Leu, Ile, Ala, Val;
- Xdd=Ser, Ala, Gly, Thr, Asn;
- Xee=Ala, Trp, His, Lys, Ser, Gly;
- Xff=Gly, Lys, Ala, Leu;
- and Xgg=Leu, Met, and a carrier or excipient, wherein SEQ ID NO:5 is other than amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.