Integrated on-chip NMR and ESR device and method for making and using the same

A method comprising:

• fabricating a space for holding a liquid sample on a substrate;
• attaching a magnet on the substrate, the magnet being capable of generating a static magnetic field across at least a portion of the space;
• and
• fabricating a microcoil on the substrate, the microcoil being capable of generating an excitation magnetic field across at least a portion of the space;
• wherein the static magnetic field and the excitation magnetic field are capable of creating Nuclear Magnetic Resonance (NMR) or Electron Spin Resonance (ESR) within a liquid sample contained in the space;
• and wherein the microcoil is capable of detecting signals from the NMR or ESR,
• wherein the substrate comprises an array of spaces for holding liquid samples and wherein each or at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces.

A method comprising:

• providing a device comprising a substrate;
• the substrate comprising a space for holding a liquid sample, a magnet capable of generating a static magnetic field across at least a portion of the space, and a microcoil capable of generating an excitation magnetic field across at least a portion of the space;
• providing a liquid sample within the space;
• using the magnet to generate a static magnetic field across at least a portion of the sample;
• using the microcoil to generate an excitation magnetic field across at least a portion of the sample;
• using the microcoil to detect signals from the sample,
• wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces.

A device comprising a substrate, the substrate comprising:

• a space for holding a liquid sample;
• and
• an array of microcoils capable of generating excitation magnetic fields across at least a portion of the space;
• wherein the excitation magnetic fields are capable of creating NMR or ESR within a liquid sample contained in the space when the sample is immersed in an static magnetic field;
• and wherein the microcoils are capable of detecting signals from the NMR or ESR,
• wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces.

A method comprising:

• providing a device comprising a substrate, the substrate comprising a space for holding a liquid sample and an array of microcoils capable of generating an excitation magnetic field across at least a portion of the space;
• providing a liquid sample within the space;
• generating a static magnetic field across at least a portion of the sample;
• using at least a portion of the microcoils to generate excitation magnetic fields across at least a portion of the sample;
• and
• using at least a portion of the microcoils to detect signals from the sample,
• wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces.