Inhibition of cellular proteases
AssigneeBoard of Regents, The University of Texas System
InventorsThomas B. Albrecht, Zhenping Chen
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Abstract
The invention provides a method of decreasing viral replication in cells, the method comprising decreasing levels of functional cellular protease in the cells. The invention further provides a method of treating or preventing a viral infection in a subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of functional cellular protease in the cells of the subject.
Claims4
A method of decreasing viral replication of a human cytomegalovirus in cells, the method comprising decreasing levels of functional cellular protease in the cells by exposing the cells to a calpain inhibitor, wherein the cells are infected with the human cytomegalovirus and wherein the calpain inhibitor is E64d or Z-Leu-Leu-H, wherein the calpain inhibitor increases the levels of p21cip1 in the cells whereby viral replication of a human cytomegalovirus is decreased.
A method of treating a viral infection of a human cytomegalovirus in a subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of functional cellular protease in cells of the subject wherein the compound increases the levels of p21cip1 in the cells whereby viral replication of a human cytomegalovirus is decreased and the compound is E64d or Z-Leu-Leu-H.
Dependencies are inferred from the claim text.