US 7,268,152 B2Granted

Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

AssigneeBoehringer Ingelheim Pharmaceuticals, Inc.

InventorsYounes Bekkali, Mario G. Cardozo, Christian Hanke Justus Joachim Harcken, Thomas M. Kirrane, Daniel Kuzmich, John Robert Proudfoot, Hossein Razavi, Hidenori Takahashi, David S. Thomson, Ji Wang, Renee Zindell

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Abstract

Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Claims11

Dependent claims

A compound of Formula (IA)

R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups,
wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, acyl, C1-C5 alkoxycarbonyl, C1-C5 alkanoyloxy, aminocarbonyl, C1-C5 alkylaminocarbonyl, C1-C5dialkylaminocarbonyl, C1-C5 aminocarbonyloxy, C1-C5 alkylaminocarbonyloxy, C1-C5 dialkylaminocarbonyloxy, C1-C5 alkanoylamino, C1-C5 alkoxycarbonylamino, C1-C5 alkylsulfonylamino, C1-C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, or amino wherein the nitrogen atom is optionally independently mono- or di-substituted by C1-C5 alkyl or aryl;
or ureido wherein either nitrogen atom is optionally independently substituted with C1-C5 alkyl;
or C1-C5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone;
wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, halogen, hydroxy, oxo, cyano, or amino,
R2 and R3 are each hydrogen;
R4 is C1-C5 alkyl optionally independently substituted with one to three substituent groups,
wherein each substituent group of R4 is independently C1-C3 alkyl, hydroxy, halogen, or oxo;
and
R5 is an aryl group optionally independently substituted with one to three substituent groups,
wherein each substituent group of R5 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, acyl, C1-C5 alkoxycarbonyl, C1-C5 alkanoyloxy, aminocarbonyl, C1-C5 alkylaminocarbonyl, C1-C5 dialkylaminocarbonyl, aminocarbonyloxy, C1-C5 alkylaminocarbonyloxy, C1-C5 dialkylaminocarbonyloxy, C1-C5 alkanoylamino, C1-C5 alkoxycarbonylamino, C1-C5 alkylsulfonylamino, C1-C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, nitro, azido, or amino wherein the nitrogen atom is optionally independently mono- or di-substituted by C1-C5 alkyl or aryl;
or ureido wherein either nitrogen atom is optionally independently substituted with C1-C5 alkyl;
or C1-C5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone,
wherein each substituent group of R5 is optionally independently substituted with one to three substituent groups selected from C1-C3 alkyl, C1-C3 alkoxy, halogen, hydroxy, oxo, cyano, amino, or trifluoromethyl,
or a tautomer, prodrug, solvate, or salt thereof.

12 more elements

A compound selected from:

2-Benzyl-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Difluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-methoxybenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-methoxybenzyl)-4-methylpentan-2-ol;
2-Biphenyl-4-ylmethyl-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(4-tert-Butylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(2-methoxybenzyl)-4-methylpentan-2-ol;
2-(3,5-Dimethoxybenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Dimethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Bromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2-Bromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2-methylbenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(3-methylbenzyl)pentan-2-ol;
2-(3,4-Difluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
5-(5-Fluoro-2-methoxyphenyl)-5-methyl-2-phenyl-3-trifluoromethylhex-1-en-3-ol;
2-(3,5-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-N-methylbenzamide;
2-(2,5-Dimethoxybenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,3-Dimethoxybenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(4-Bromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Bis-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(3,4,5-trifluorobenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-5-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(4-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(3-trifluoromethylbenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-trifluoromethylbenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-trifluoromethoxybenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-naphthalen-2-ylmethylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-naphthalen-1-ylmethylpentan-2-ol;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-(3,5-Di-tert-butylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-trifluoromethylsulfanylbenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-methylbenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-vinylbenzyl)pentan-2-ol;
2-(3,5-Dibromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(2-fluoro-3-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(2-fluoro-5-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3-Chloro-5-methylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-fluoro-3-methylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-2-(2-fluorobenzyl)-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-2-(4-fluorobenzyl)-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2,3,5-trifluorobenzyl)pentan-2-ol;
6-(5-Fluoro-2-methoxyphenyl)-6-methyl-1-phenyl-4-trifluoromethylheptan-4-ol;
2-(5-Fluoro-2-methoxyphenyl)-2,6-dimethyl-6-phenyl-4-trifluoromethylheptan-4-ol;
2-(4-Chloro-3-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2-methylnaphthalen-1-ylmethyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-methylnaphthalen-1-ylmethyl)pentan-2-ol;
2-(3-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,3-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(5-Chloro-2-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-isopropylbenzyl)-4-methylpentan-2-ol;
2-(2,6-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Fluoro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-(2-Chloro-3-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Chloro-4-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,5-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-methoxy-3-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3,4-Dimethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,4-Dimethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-4-methylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-4-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-fluoro-3-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2,3,5-trichlorobenzyl)pentan-2-ol;
2-(3,5-Dimethylbenzyl)-1,1,1-trifluoro-4-(2-methoxyphenyl)-4-methylpentan-2-ol;
4-(2,3-Dihydrobenzofuran-7-yl)-2-(3,5-dimethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(2,3-dihydrobenzofuran-7-yl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-Benzyl-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-Benzyl-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-Biphenyl-4-ylmethyl-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(4-tert-Butylbenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3,5-Dichlorobenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
4-(4-Chlorophenyl)-2-(3,4-dichlorobenzyl)-1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(4-chlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(4-fluorophenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(4-fluorophenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(3-chlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
4-(3-Chlorophenyl)-2-(3,4-dichlorobenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(3,4-dichlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-p-tolylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(3-fluorophenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(3-pyridin-3-ylbenzyl)pentan-2-ol;
2-Biphenyl-3-ylmethyl-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-2-(5′-fluoro-2′-methoxybiphenyl-3-ylmethyl)-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2′,5′-Dichlorobiphenyl-3-ylmethyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2′-trifluoromethylbiphenyl-3-ylmethyl)pentan-2-ol;
1,1,1-Trifluoro-2-(5′-fluoro-2′-methoxybiphenyl-4-ylmethyl)-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3′-Chloro-4′-fluorobiphenyl-4-ylmethyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(5′-isopropyl-2′-methoxybiphenyl-4-ylmethyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2′,4′,6′-trichlorobiphenyl-4-ylmethyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-pyridin-3-ylbenzyl)pentan-2-ol;
2-(3-Benzyl-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl)-4-fluorophenol;
2-(3-Biphenyl-4-ylmethyl-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl)-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-3-(4-hydroxybenzyl)-1,1-dimethylbutyl]phenol;
2-(3-Biphenyl-2-ylmethyl-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl)-4-fluorophenol;
2-[3-(3,5-Dimethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(2-methylbenzyl)butyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3-methylbenzyl)butyl]phenol;
2-[3-(3,4-Difluorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3-pyridin-3-ylbenzyl)butyl]phenol;
2-(3-Biphenyl-3-ylmethyl-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl)-4-fluorophenol;
2-[3-(3,5-Dichlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
2-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzene-1,4-diol;
2-[3-(2′,5′-Dichlorobiphenyl-3-ylmethyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
3-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzene-1,2-diol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-3-(2-hydroxybenzyl)-1,1-dimethylbutyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-3-(4-methanesulfonylbenzyl)-1,1-dimethylbutyl]phenol;
2-[3-(4-Chlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(4-vinylbenzyl)butyl]phenol;
2-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3,5-Difluorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3,5-Bistrifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[3-(3-Chloro-5-methylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3,4,5-trifluorobenzyl)butyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(3-fluoro-5-trifluoromethylbenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
2-[3-(3,5-Dibromobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(2-fluorobenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(4-fluoro-3-methylbenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(4-fluorobenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-3-(4-isopropylbenzyl)-1,1-dimethylbutyl]phenol;
2-[3-(3,4-Dichlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(2-ethoxy-5-fluorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
4-(2-Allyloxy-5-fluorophenyl)-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-{2-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenoxy}acetamide;
3-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzamide;
4-Benzofuran-7-yl-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
5-(5-Fluoro-2-methoxyphenyl)-5-methyl-1-phenyl-3-trifluoromethylhexan-3-ol;
1-(3,5-Dimethylphenyl)-5-(5-fluoro-2-methoxyphenyl)-5-methyl-3-trifluoromethylhexane-2,3-diol;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzamide;
1-(3,5-Dimethylphenyl)-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethylpentane-1,2-diol;
1-(3,5-Dimethylphenyl)-5-(5-fluoro-2-methoxyphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexan-2-one;
2-(5-Bromo-2-fluoro-3-methylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-(4-methoxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[3-(5-Bromo-2-fluoro-3-methylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
3-Chloro-4-[2-hydroxy-4-(4-hydroxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxymethoxyphenyl)-4-methylpentan-2-ol;
4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-(5-nitro-2,3-dihydrobenzofuran-7-yl)pentan-2-ol;
7-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-2,3-dihydrobenzofuran-5-carbonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde;
1-(3,5-Dimethylphenyl)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentan-1-one;
3-Chloro-4-(2-hydroxy-4-methyl-4-o-tolyl-2-trifluoromethylpentyl)benzonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzoic acid;
{2-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenoxy}acetic acid;
7-[3-(2-Chloro-4-cyanobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-2,3-dihydrobenzofuran-5-carbonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(5-fluoro-2-methoxyphenyl)cyclopropylmethyl]-2-bydroxypropyl}benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-tolyl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-quinolin-4-yl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-hydroxy-2-[1-(2-trifluoromethoxyphenyl)cyclopropylmethyl]propyl}benzonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(5-fluoro-2-hydroxyphenyl)cyclopropylmethyl]-2-hydroxypropyl}benzonitrile;
1-{3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}ethanone;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde;
2-(2-Chloro-4-hydroxymethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-4-[4-(3-ethyl-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
4-[4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-3-chlorobenzonitrile;
3-Chloro-4-[4-(3-ethyl-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-{2-[1-(2,5-difluorophenyl)cyclopropylmethyl]-3,3,3-trifluoro-2-hydroxypropyl}benzonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(4-fluorophenyl)cyclopropylmethyl]-2-hydroxypropyl}benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde oxime;
1-{3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}ethanone oxime;
3-Chloro-4-[4-(5-fluoro-2-methylphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(4-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(3-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-4,6-dimethylbenzonitrile;
4-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-2,6-dimethylbenzonitrile;
3-Chloro-4-[2-hydroxy-4-(3-methoxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(3-trifluoromethylphenyl)pentyl]benzonitrile;
2-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-4,6-dimethylbenzonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-2,6-dimethylbenzonitrile;
3-Chloro-4-[4-(4-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(4-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(3,5-dimethoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
4-[4-(5-Bromo-4-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-3-chlorobenzonitrile;
3-Chloro-4-[4-(3,5-dihydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-4-(5-methyl-2,3-dihydrobenzofuran-7-yl)-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-(1-methoxynaphthalen-2-yl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-naphthalen-2-yl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-{2-[1-(2-chloro-5-fluorophenyl)cyclobutylmethyl]-3,3,3-trifluoro-2-hydroxypropy}benzonitrile;
3-Chloro-4-[4-(2,3-dihydrobenzofuran-5-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-phenyl-2-trifluoromethylpentyl)benzonitrile;
2-(4-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(4-trifluoromethylphenyl)pentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(2-trifluoromethylphenyl)pentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(4-trifluoromethylphenyl)pentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-p-totyl-2-trifluoromethylpentyl)benzonitrile;
{4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}phenylmethanone;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]naphthalene-1-carbonitrile;
4-[4-(2,3-Dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]naphthalene-1-carbonitrile;
2-[4-(5-Chlorothiophen-2-yl)benzyl]-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
and
1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2′-trifluoromethylbiphenyl-3-ylmethyl)pentan-2-ol,
or a tautomer, prodrug, solvate, or salt thereof.

205 more elements

A compound selected from:

2-Benzyl-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Difluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-methoxybenzyl)-4-methylpentan-2-ol;
2-Biphenyl-4-ylmethyl-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Dimethoxybenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Dimethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Bromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,4-Difluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(4-Bromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Bis-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(3,4,5-trifluorobenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-5-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(4-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(3-trifluoromethylbenzyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-naphthalen-2-ylmethylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-naphthalen-1-ylmethylpentan-2-ol;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-vinylbenzyl)pentan-2-ol;
2-(3,5-Dibromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(2-fluoro-3-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(2-fluoro-5-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3-Chloro-5-methylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-fluoro-3-methylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-2-(2-fluorobenzyl)-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2,3,5-trifluorobenzyl)pentan-2-ol;
2-(4-Chloro-3-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2-methylnaphthalen-1-ylmethyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-methylnaphthalen-1-ylmethyl)pentan-2-ol;
2-(2,3-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(5-Chloro-2-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Fluoro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-(2-Chloro-3-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Chloro-4-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,5-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-methoxy-3-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3,4-Dimethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-4-methylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-4-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(4-fluoro-3-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2,3,5-trichlorobenzyl)pentan-2-ol;
2-(3,5-Dimethylbenzyl)-1,1,1-trifluoro-4-(2-methoxyphenyl)-4-methylpentan-2-ol;
4-(2,3-Dihydrobenzofuran-7-yl)-2-(3,5-dimethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(2,3-dihydrobenzofuran-7-yl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-Benzyl-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-Biphenyl-4-ylmethyl-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3,5-Dichlorobenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(4-chlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(4-fluorophenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(4-fluorophenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(3-chlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
4-(3-Chlorophenyl)-2-(3,4-dichlorobenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(3,4-dichlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-p-tolylpentan-2-ol;
2-(3′-Chloro-4′-fluorobiphenyl-4-ylmethyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2′,4′,6′-trichlorobiphenyl-4-ylmethyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-pyridin-3-ylbenzyl)pentan-2-ol;
2-(3-Benzyl-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl)-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-3-(4-hydroxybenzyl)-1,1-dimethylbutyl]phenol;
2-[3-(3,5-Dimethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(2-methylbenzyl)butyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3-methylbenzyl)butyl]phenol;
2-[3-(3,4-Difluorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3-pyridin-3-ylbenzyl)butyl]phenol;
2-[3-(3,5-Dichlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
2-[3-(4-Chlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3,5-Difluorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3,5-Bis-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[3-(3-Chloro-5-methylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3,4,5-trifluorobenzyl)butyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(3-fluoro-5-trifluoromethylbenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
2-[3-(3,5-Dibromobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(2-fluorobenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(4-fluoro-3-methylbenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(4-fluorobenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
2-[3-(3,4-Dichlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(2-ethoxy-5-fluorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
4-(2-Allyloxy-5-fluorophenyl)-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
3-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzamide;
4-Benzofuran-7-yl-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzamide;
1-(3,5-Dimethylphenyl)-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethylpentane-1,2-diol;
1-(3,5-Dimethylphenyl)-5-(5-fluoro-2-methoxyphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexan-2-one;
2-(2-Bromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Biphenyl-4-ylmethyl-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl)-4-fluorophenol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(5-Bromo-2-fluoro-3-methylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-(4-methoxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[3-(5-Bromo-2-fluoro-3-methylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
3-Chloro-4-[2-hydroxy-4-(4-hydroxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxymethoxyphenyl)-4-methylpentan-2-ol;
4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-(5-nitro-2,3-dihydrobenzofuran-7-yl)pentan-2-ol;
7-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-2,3-dihydrobenzofuran-5-carbonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde;
3-Chloro-4-(2-hydroxy-4-methyl-4-o-tolyl-2-trifluoromethylpentyl)benzonitrile;
7-[3-(2-Chloro-4-cyanobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-2,3-dihydrobenzofuran-5-carbonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(5-fluoro-2-methoxyphenyl)cyclopropylmethyl]-2-hydroxypropyl}benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-m-tolyl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-quinolin-4-yl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-hydroxy-2-[1-(2-trifluoromethoxyphenyl)cyclopropylmethyl]propyl}benzonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(5-fluoro-2-hydroxyphenyl)cyclopropylmethyl]-2-hydroxypropyl}benzonitrile;
1-{3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}ethanone;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde;
2-(2-Chloro-4-hydroxymethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-4-[4-(3-ethyl-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
4-[4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-3-chlorobenzonitrile;
3-Chloro-4-[4-(3-ethyl-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-{2-[1-(2,5-difluorophenyl)cyclopropylmethyl]-3,3,3-trifluoro-2-hydroxypropyl}benzonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(4-fluorophenyl)cyclopropylmethyl]-2-hydroxypropyl}benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde oxime;
1-{3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}ethanone oxime;
3-Chloro-4-[4-(5-fluoro-2-methylphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(4-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(3-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-4,6-dimethylbenzonitrile;
4-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-2,6-dimethylbenzonitrile;
3-Chloro-4-[2-hydroxy-4-(3-methoxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(3-trifluoromethylphenyl)pentyl]benzonitrile;
2-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-4,6-dimethylbenzonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-2,6-dimethylbenzonitrile;
3-Chloro-4-[4-(4-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(4-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(3,5-dimethoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
4-[4-(5-Bromo-4-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-3-chlorobenzonitrile;
3-Chloro-4-[4-(3,5-dihydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-4-(5-methyl-2,3-dihydrobenzofuran-7-yl)-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-(1-methoxynaphthalen-2-yl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-naphthalen-2-yl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-{2-[1-(2-chloro-5-fluorophenyl)cyclobutylmethyl]-3,3,3-trifluoro-2-hydroxypropyl}benzonitrile;
3-Chloro-4-[4-(2,3-dihydrobenzofuran-5-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-phenyl-2-trifluoromethylpentyl)benzonitrile;
2-(4-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(2-trifluoromethylphenyl)pentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(4-trifluoromethylphenyl)pentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-p-tolyl-2-trifluoromethylpentyl)benzonitrile;
{4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}phenylmethanone;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]naphthalene-1-carbonitrile;
4-[4-(2,3-Dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]naphthalene-1-carbonitrile;
and
2-[4-(5-Chlorothiophen-2-yl)benzyl]-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol,
or a tautomer, prodrug, solvate, or salt thereof.

155 more elements

A compound selected from:

2-(3,5-Difluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-Biphenyl-4-ylmethyl-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Dimethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Bromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,5-Bis-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-5-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-(3,5-Dibromobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(2-fluoro-3-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(2-fluoro-5-trifluoromethylbenzyl)-4-methylpentan-2-ol;
2-(3-Chloro-5-methylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2,3,5-trifluorobenzyl)pentan-2-ol;
2-(4-Chloro-3-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2-methylnaphthalen-1-ylmethyl)pentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(4-methylnaphthalen-1-ylmethyl)pentan-2-ol;
2-(2,3-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(5-Chloro-2-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Fluoro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-(3-Chloro-4-fluorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(2,5-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
2-(3,4-Dimethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(3-fluoro-4-trifluoromethylbenzyl)-4-methylpentan-2-ol;
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(2,3,5-trichlorobenzyl)pentan-2-ol;
2-(3,5-Dimethylbenzyl)-1,1,1-trifluoro-4-(2-methoxyphenyl)-4-methylpentan-2-ol;
4-(2,3-Dihydrobenzofuran-7-yl)-2-(3,5-dimethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(2,3-dihydrobenzofuran-7-yl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-Benzyl-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3,5-Dichlorobenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-methyl-4-phenylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(4-fluorophenyl)-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(3-chlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
4-(3-Chlorophenyl)-2-(3,4-dichlorobenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(3,4-dichlorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methylpentan-2-ol;
2-(3,4-Dichlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methylpentan-2-ol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-3-(4-hydroxybenzyl)-1,1-dimethylbutyl]phenol;
2-[3-(3,5-Dimethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(2-methylbenzyl)butyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3-methylbenzyl)butyl]phenol;
2-[3-(3,4-Difluorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
2-[3-(3,5-Dichlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]4-fluorophenol;
2-[3-(4-Chlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3,5-Difluorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-[3-(3,5-Bis-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[3-(3-Chloro-5-methylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(3,4,5-trifluorobenzyl)butyl]phenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(3-fluoro-5-trifluoromethylbenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
2-[3-(3,5-Dibromobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
4-Fluoro-2-[4,4,4-trifluoro-3-(4-fluoro-3-methylbenzyl)-3-hydroxy-1,1-dimethylbutyl]phenol;
2-[3-(3,4-Dichlorobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4-(2-ethoxy-5-fluorophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
4-Benzofuran-7-yl-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
1-(3,5-Dimethylphenyl)-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethylpentane-1,2-diol;
1-(3,5-Dimethylphenyl)-5-(5-fluoro-2-methoxyphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexan-2-one;
2-(5-Bromo-2-fluoro-3-methylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-(4-methoxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[3-(5-Bromo-2-fluoro-3-methylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-4-fluorophenol;
3-Chloro-4-[2-hydroxy-4-(4-hydroxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-(3-chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methylpentan-2-ol;
2-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-1,1,1-trifluoro-4-methyl-4-(5-nitro-2,3-dihydrobenzofuran-7-yl)pentan-2-ol;
7-[3-(3-Chloro-2-fluoro-5-trifluoromethylbenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-2,3-dihydrobenzofuran-5-carbonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde;
3-Chloro-4-(2-hydroxy-4-methyl-4-o-tolyl-2-trifluoromethylpentyl)benzonitrile;
7-[3-(2-Chloro-4-cyanobenzyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl]-2,3-dihydrobenzofuran-5-carbonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(5-fluoro-2-methoxyphenyl)cyclopropylmethyl]-2-hydroxypropyl}benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-m-tolyl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-{3,3,3-trifluoro-2-[1-(5-fluoro-2-hydroxyphenyl)cyclopropylmethyl]-2-hydroxypropyl}benzonitrile;
1-{3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}ethanone;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde;
2-(2-Chloro-4-hydroxymethylbenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
4-[4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-3-chlorobenzonitrile;
3-Chloro-4-[4-(3-ethyl-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzaldehyde oxime;
1-{3-Chloro-4-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]phenyl}ethanone oxime;
3-Chloro-4-[4-(5-fluoro-2-methylphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(4-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(3-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
2-[4-(5-Fluoro-2-hydroxypenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-4,6-dimethylbenzonitrile;
4-[4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-2,6-dimethylbenzonitrile;
3-Chloro-4-[2-hydroxy-4-(3-methoxyphenyl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(3-trifluoromethylphenyl)pentyl]benzonitrile;
2-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-4,6-dimethylbenzonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-2,6-dimethylbenzonitrile;
3-Chloro-4-[4-(4-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(4-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(3,5-dimethoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
4-[4-(5-Bromo-4-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-3-chlorobenzonitrile;
3-Chloro-4-[4-(3,5-dihydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-4-(5-methyl-2,3-dihydrobenzofuran-7-yl)-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-(1-methoxynaphthalen-2-yl)-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-naphthalen-2-yl-2-trifluoromethylpentyl)benzonitrile;
3-Chloro-4-{2-[1-(2-chloro-5-fluorophenyl)cyclobutylmethyl]-3,3,3-trifluoro-2-hydroxypropyl}benzonitrile;
3-Chloro-4-[4-(2,3-dihydrobenzofuran-5-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-phenyl-2-trifluoromethylpentyl)benzonitrile;
2-(4-Chlorobenzyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(2-trifluoromethylphenyl)pentyl]benzonitrile;
3-Chloro-4-[2-hydroxy-4-methyl-2-trifluoromethyl-4-(4-trifluoromethylphenyl)pentyl]benzonitrile;
3-Chloro-4-(2-hydroxy-4-methyl-4-p-tolyl-2-trifluoromethylpentyl)benzonitrile;
4-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]naphthalene-1-carbonitrile;
and
4-[4-(2,3-Dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]naphthalene-1-carbonitrile,
or a tautomer, prodrug, solvate, or salt thereof.

113 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/394,157Filed 21 Mar 2003 · us provisional application
Priority: 26 Mar 2002
Published: US 2004/0029932 A112 Feb 2004
Granted: 11 Sep 2007
Term ends: Not estimatedThe source records don’t support an estimate.

Classification64 codes

C07C 323/18
Containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton: having the sulfur atom of at least one of the thio groups…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents