System and methods for optimized drug delivery and progression of diseased and normal cells

A computer-implemented method for modelling neutrophil lineage and for recommending an optimal treatment protocol for granulopoietic disorders for an individual, said computer-implemented method comprising:

• creating a neutrophil system model including a process model for cells involved in neutrophil lineage;
• modifying the system model based on parameters specific to the individual;
• and
• using the modified model to provide neotrophil lineage for the individual,
• recommending an optimum treatment protocol for granulopoietic disorders to a user,
• wherein said model comprises a mitotic compartment, and a post mitotic compartment, said mitotic compartment being divided into subcompartments wherein a kth sub-compartment contains cells of age between k−1 and k hours relative to a time of entry into the mitotic compartment,
• wherein effects of toxic drugs are incorporated by mapping various cell-cycle phases to the sub-compartments and formulating a function of cytotoxic effects of toxic drugs.

A computer-implemented method for modelling neutrophil lineage for a general patient and for recommending an optimal treatment protocol for granulopoietic disorders, said computer-implemented method comprising:

• creating a neutrophil system model including a process model for cells involved in neutrophil lineage, and
• using the model to provide a neutrophil lineage for a general patient,
• recommending an optimum treatment protocol for granulopoietic disorders to a user
• wherein said model comprises a mitotic compartment, and a post mitotic compartment, said mitotic compartment being divided into subcompartments wherein a kth sub-compartment contains cells of age between k−1 and k hours relative to a time of entry into the mitotic compartment,
• wherein effects of toxic drugs are incorporated by mapping various cell-cycle phases to the sub-compartments and formulating a function of cytotoxic effects of toxic drugs, including chemotherapy on the cell-cycle phases.