Composition and method for treating cancer using herpes virus
AssigneesM's Science Corporation, Yukihiro Nishiyama
InventorYukihiro Nishiyama
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Abstract
The present invention provides a herpes virus in which a non-essential gene for replication is inactivated More particularly, the present invention provides a herpes virus in which a non-essential gene for replication present in a UL or US region is inactivated. More preferably, the non-essential gene for replication contains US3 or UL56. The herpes virus may be preferably a herpes simplex virus, and more preferably herpes simplex virus 1 or herpes simplex virus 2. The present invention provides a method, composition and use for treating various diseases or disorders including tumor and infectious diseases. The present invention also provides a method, composition and use for activating a prodrug.
Claims9
A herpes virus, wherein at least two non-essential genes for replication thereof are inactivated and further wherein the herpes virus is herpes simplex virus, wherein the first non-essential gene is UL56 and the second non-essential gene for replication is UL43.
Dependencies are inferred from the claim text.