US 7,264,810 B2 · Molecular antigen array

Abstract

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.

Claims218

Dependent claims

A composition comprising:

(a) a non-natural molecular scaffold comprising:
(i) a core particle comprising a virus-like particle of an RNA bacteriophage;
and
(ii) an organizer comprising at least one first attachment site, wherein said organizer is connected to said core particle by at least one covalent bond;
and wherein said first attachment site is not a sulfhydryl group;
and
(b) an antigen or antigenic determinant with at least one second attachment site,
wherein said antigen or antigenic determinant is at least one self antigen, a peptide thereof, or fragment thereof, wherein said self antigen is not amyloid β or a peptide of fragment thereof;
wherein said second attachment site is capable of association through at least one non-peptide bond to said first attachment site;
and
wherein said antigen or antigenic determinant and said scaffold interact through said association to form an ordered and repetitive antigen array.

8 more elements

Dependencies are inferred from the claim text.

Molecular antigen array

Life of this patent

Molecular antigen array

Life of this patent

Abstract

Claims218