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US 7,262,209 B2Granted
Carbonyloxy-cyanomethyl compounds as antiparasitic agents
AssigneeNovartis Animal Health US, Inc.
InventorsThomas Goebel, Pierre Ducray
Life of this patent
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Abstract
The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances given in the specification, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
Claims39
A compound of formula (I)
- wherein
- Ar1 and Ar2, independently of one another, signify unsubstituted phenyl or phenyl which is substituted once or many times, whereby the substituents may be independent of one another and are selected from the group consisting of halogen, nitro, cyano, C1–C6-alkyl, halo-C1–C6-alkyl, C1–C6-alkoxy, halo-C1–C6-alkoxy, C2–C6-alkenyl, halo-C2–C6-alkenyl, C2–C6-alkinyl, C3–C6-cycloalkyl, C2–C6-alkenyloxy, halo-C2–C6-alkenyloxy, C1–C6-alkylthio, halo-C1–C6-alkylthio, C1–C6-alkylsulfonyloxy, halo-C1–C6-alkylsulfonyloxy, C1–C6-alkylsulfinyl, halo-C1–C6-alkylsulfinyl, C1–C6-alkylsulfonyl, halo-C1–C6-alkylsulfonyl, C2-C6-alkenylthio, halo-C2–C6-alkenylthio, C2–C6-alkenylsulfinyl, halo-C2–C6-alkenylsulfinyl, C2–C6-alkenylsulfonyl, halo-C2–C6-alkenylsulfonyl, C1–C6-alkylamino, di-C1–C6-alkylamino, C1–C6-alkylsulfonylamino, halo-C1–C6-alkylsulfonylamino, C1–C6-alkylcarbonyl, halo-C1–C6-alkylcarbonyl, C1–C6-alkoxycarbonyl, C1–C6-alkylaminocarbonyl, di-C1–C6-alkylaminocarbonyl;
- unsubstituted phenylamino or phenylamino which is substituted once or many times;
- unsubstituted phenylcarbonyl or phenylcarbonyl which is substituted once or many times;
- unsubstituted phenyl or phenyl which is substituted once or many times, whereby the substituents may be independent of one another and are selected from the group consisting of halogen, nitro, cyano, C1–C6-alkyl, halo-C1–C6-alkyl, C1–C6-alkoxy, halo-C1–C6-alkoxy, C1–C6-alkylthio, halo-C1–C6-alkylthio, C1–C6-alkylsulfinyl, halo-C1–C6-alkylsulfinyl, C1–C6-alkylsulfonyl and halo-C1–C6-alkylsulfonyl;
- unsubstituted phenoxy or phenoxy which is substituted once or many times, whereby the substituents may be independent of one another and are selected from the group consisting of halogen, nitro, cyano, C1–C6-alkyl, halo-C1–C6-alkyl, C1–C6-alkoxy, halo-C1–C6-alkoxy, C1–C6-alkylthio, halo-C1–C6-alkylthio, C1–C6-alkylsulfinyl, halo-C1–C6-alkylsulfinyl, C1–C6-alkylsulfonyl and halo-C1–C6-alkylsulfonyl;
- unsubstituted phenylacetylenyl or phenylacetylenyl which is substituted once or many times, whereby the substituents may be independent of one another and are selected from the group consisting of halogen, nitro, cyano, C1–C6-alkyl, halo-C1–C6-alkyl, C1–C6-alkoxy, halo-C1–C6-alkoxy, C1–C6-alkylthio, halo-C1–C6-alkylthio, C1–C6-alkylsulfinyl, halo-C1–C6-alkylsulfinyl, C1–C6-alkylsulfonyl and halo-C1–C6-alkylsulfonyl;
- and unsubstituted pyridyloxy or pyridyloxy which is substituted once or many times, whereby the substituents may be independent of one another and are selected from the group consisting of halogen, nitro, cyano, C1–C6-alkyl, halo-C1–C6-alkyl, C1–C6-alkoxy, halo-C1–C6-alkoxy, C1–C6-alkylthio, halo-C1–C6-alkylthio, C1–C6-alkylsulfinyl, halo-C1–C6-alkylsulfinyl, C1–C6-alkylsulfonyl and halo-C1–C6-alkylsulfonyl;
- halo-C2–C6-alkenylsulfinyl, C1–C6-alkylsulfonyl and halo-C1–C6-alkylsulfonyl,
- R4, R5, R6, R7 and R8 are either, independently of one another, hydrogen, halogen, unsubstituted C1–C6-alkyl or C1–C6-alkyl which is substituted once or many times, unsubstituted C2–C6-alkenyl or C2–C6-alkenyl which is substituted once or many times, unsubstituted C2–C6-alkinyl or C2–C6-alkinyl which is substituted once or many times, whereby the substituents may each be independent of one another and are selected from the group consisting of halogen, C1–C6-alkoxy and halo-C1–C6-alkoxy;
- C3–C6-cycloalkyl, whereby the substituents may be independent of one another and are selected from the group consisting of halogen and C1–C6-alkyl;
- unsubstituted phenyl or phenyl which is substituted once or many times, whereby the substituents may be independent of one another and are selected from the group consisting of halogen, nitro, cyano, C1–C6-alkyl, halo-C1–C6-alkyl, C1–C6-alkoxy, halo-C1–C6-alkoxy, C1–C6-alkylthio, halo-C1–C6-alkylthio, C1–C6-alkylsulfinyl, halo-C1–C6-alkylsulfinyl, C1–C6-alkylsulfonyl, halo-C1–C6-alkylsulfonyl, C1–C6-alkylamino or di-C1–C6-alkylamino;
- or R4 and R5 together signify C2–C6-alkylene;
- W signifies O, S, S(O2) or N(R9);
- R9 signifies hydrogen or C1–C6-alkyl;
- X signifies O, S or N(R10);
- R10 signifies hydrogen, C1–C6-alkyl, halo-C1–C6-alkyl, allyl or C1–C6-alkoxymethyl;
- a signifies 1, 2, 3 or 4;
- and
- b signifies 0, 1, 2, 3 or 4, whereby said compound is in free form or salt form.
17 more elements
Dependencies are inferred from the claim text.