Microdevices having a preferential axis of magnetization and uses thereof
AssigneeAviva Biosciences Corporation
InventorsMingxian Huang, Lei Wu, Xiaobo Wang, Junquan Xu, Guo Liang Tao, David M. Rothwarf
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Abstract
This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
Claims16
A method for manipulating a plurality of microdevices in an array of microchannels, which method comprises:
- a) providing a plurality of microdevices, each said microdevice comprising
- 1) a magnetizable substance;
- and
- 2) a photorecognizable coding pattern, wherein each said microdevice has a preferential axis of magnetization that is substantially aligned with the microdevice's major axis;
- b) providing a microchannel array comprising a plurality of microchannels, said microchannels are sufficiently wide to permit rotation of said microdevices within said microchannels but sufficiently narrow to prevent said microdevices from forming a chain when the major axis of said microdevices is substantially perpendicular to the major axis of said microchannels;
- and wherein the height of the microchannels and/or a constraint on the microdevices by a magnetic field does not allow the microdevices to stand up within the microchannels;
- c) introducing said plurality of microdevices into said plurality of microchannels;
- and
- d) rotating said microdevices within said microchannels by a magnetic force, whereby a combined effect of said magnetic force and said preferential axis of magnetization of said microdevices substantially separates said microdevices from each other.
The method of claim , wherein the microdevices are introduced into the microchannels by a magnetic force, a fluidic force or a combination thereof.
Dependencies are inferred from the claim text.