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US 7,261,891 B2Granted
Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease
AssigneePromega Corporation
InventorsJohn A. Kink, Katherine L. Worledge, Douglas C. Stafford
Life of this patent
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Abstract
Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to proinflammatory cytokines (such as IL-6 and TNF) are shown to have a beneficial effect in animal models predictive of human therapy for the treatment of colitis, including Crohn's disease.
Claims7
A method comprising:
- a) providing:
- i) a human patient with symptoms of inflammatory bowel disease, and
- ii) a therapeutic formulation comprising antibodies purified from an avian egg yolk, wherein said antibodies are directed to human Tumor Necrosis Factor Alpha;
- and
- b) administering said formulation to the lumen of the intestine of said patient under conditions such that at least one of said symptoms is reduced.
2 more elements
Dependencies are inferred from the claim text.